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The One Lambda Devyser Chimerism NGS assay offers a high-throughput, sensitive solution for the detection of the recipient microchimerism at an early stage, which may be a sign for graft rejection and disease relapse enabling optimized patient management for bone marrow transplant patients.
Key features and benefits
- Comprehensive coverage: Utilizes 24 indel markers to detect microchimerism in post-hematopoietic stem cell transplantation (HSCT) samples
- Confidence in results: Achieves results with sensitivity down to >0.05%
- Efficient workflow: Utilize a single universal mix and one workflow for both screening and monitoring, reduces hands-on time to as little as 45 minutes, and delivers next-day sequencing results
- Simplified analysis: User-friendly software simplifies chimerism assessment, enables flexible data presentation, and provides longitudinal tracking, all within one dedicated software
- Expert support: Our dedicated team of scientists and specialists are available to answer your questions, interpret data, and guide you towards optimal use of One Lambda Devyser NGS Assay
What is the One Lambda Devyser Chimerism assay?
The next generation of chimerism testing
Designed to provide accurate and sensitive detection of microchimerism levels in stem cell transplant samples, the One Lambda Devyser Chimerism NGS Assay is a post-transplant monitoring solution that is perfect for HLA and molecular core labs associated with HSCT Programs. It offers a fast and repeatable workflow from patient sample to report and a unified workflow for screening and monitoring. One tube per sample avoids any need for sample splitting, and the single measurement method is independent of mixed chimerism levels. Leveraging next-generation sequencing (NGS) technology, our assay offers an unparalleled limit of detection of 0.05%, enabling the identification of small changes in chimerism status.
Fig. 1. Measured vs theoretical target chimerism %.
How does One Lambda Devyser Chimerism assay work?
Seamless workflow for maximum efficiency
Our One Lambda Devyser Chimerism NGS Assay offers a seamless workflow that requires as little as 45 minutes of hands-on time, delivers results within 24 hours, and helps ensure maximum efficiency in your laboratory. By utilizing a single protocol, you can easily perform both screening and monitoring together and eliminate the need for sample-specific primers and patient-specific marker tracking. The universal reagent mix allows for cost-effective testing, reducing reagent wastage and the need to keep multiple reagents in stock.
Highly accurate results with unmatched sensitivity
The One Lambda Devyser Chimerism NGS Assay combines the sensitivity of real-time PCR analysis and the precision of STR based analysis. The unique 24-indel panel allows for accurate detection and monitoring of microchimerism, irrespective of mixed chimerism levels.1,2 With one tube per sample, there's no need for sample splitting, ensuring optimal sample integrity and reliable results.
Fig. 2. Genetic markers distributed over 17 chromosomes.
Dedicated software for fast and accurate result analysis
You can easily assess chimerism, sample type, and longitudinal tracking with the One Lambda Devyser Chimerism NGS Assay and its dedicated software. The dedicated data analysis software delivers precise and speedy chimerism status information. The user-friendly interface and flexible data display simplify data interpretation. With this comprehensive sample-to-result solution, you can optimize your lab resources while providing top-quality results.
Fig. 3. User interface example.
Unlock the full potential of chimerism testing
Enhance your post-transplant monitoring capabilities and join the next generation of chimerism testing with the One Lambda Devyser Chimerism NGS Assay. Detect microchimerism and monitor graft rejection and disease relapse in stem cell transplant at an early stage, enabling timely interventions and improved transplant outcomes.
Resources
Advanced molecular transplant monitoring solutions with the Devyser and Thermo Fisher Scientific partnership
The partnership between Devyser and Thermo Fisher Scientific combines expertise and resources to offer enhanced and cutting-edge molecular kidney transplant monitoring capabilities to transplant programs, HLA labs, and transplant clinicians. Backed by Thermo Fisher Scientific's robust commercial infrastructure, our collaboration ensures reliable, accurate, and high-quality testing solutions for healthcare providers worldwide.
Product is IVDR certified but not 510(k) cleared. Availability of the product in each country depends on local regulatory marketing authorization status. Dvysr is a trademark of Devyser AB. Not all products are available in all countries. Please consult your local sales representative for details.