Perform the highest - quality native intact mass and top-down analysis in structural biology and biopharma research. The Thermo Scientific™ Q Exactive™ UHMR (Ultra-High Mass Range) Hybrid Quadrupole-Orbitrap™ Mass Spectrometer is the first UHMR MS to combine substantially increased sensitivity and mass resolution at high m/z, MS2, and psuedo-MS3 capabilities in a single platform.
Confidently resolve small mass differences
Analyze intact megaDalton assemblies and resolve small differences in masses that reveal key ligands, modifications and interactions for better understanding of biological processes.Conserve precious sample
Samples are often precious and only available in limited amounts. With orders of magnitude enhanced sensitivity at high m/z, you can make high-confidence measurements, even if you have very little sample to work with.Rapidly perform top-down MS analysis of native proteins
Ultra-high mass quadrupole selection up to 25k m/z and higher fragmentation efficiency in the injection flatapole and HCD cell region allow native top down analysis.Characterize intact native protein assemblies, including membrane proteins
By varying the in-source trapping energy, the instrument can release protein subunits for top-down sequencing or, with gentle activation, retain membrane proteins bound to multiple ligands allowing whole complex analysis.
Separate even the most complex samples with our extensive portfolio of innovative Thermo Scientific HPLC and UHPLC systems.
Screen, identify and characterize intact proteins with higher productivity using Biopharma Finder.