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ACVR2B Recombinant Human Protein (without catalytic activity domain), hIgG1-Fc tag

Catalog number: 10229H02H50

 Related applications: Protein Assays and Analysis

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Activin Receptor IIB (ACVR2B), recombinant human protein is supplied as a lyophilized powder. In general, recombinant proteins are suitable for use in studying protein-protein interactions, analysis of protein structure, and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applicationsThis recombinant protein was expressed from a DNA sequence encoding the N-terminal segment (Met 1-Thr 134) from the extracellular domain of human ACVR2B (NP_001097.2) was expressed with the fused human IgG1 Fc region at the C-terminus.

Activity: 1. Measured by its dose-dependent blocking of myostatin inhibition on murine MPC-11 cell proliferation. Approximately 11 ng/ml of recombinant human ActivinR-IIB/Fc Chimera will inhibit 50% of the biological response due to 4 ng/ml of myostatin.
2. Measured by its binding ability in a functional ELISA.
3. Immobilized human ACVR2B (Cat:10229-H02H) at 10 µg/ml (100 µl/well) can bind biotinylated human INHBA-His (Cat:10429-H08H), The EC50 of biotinylated human INHBA-His (Cat:10429-H08H) is 0.112 µg/ml.
4. Immobilized human ACVR2B (Cat:10229-H02H) at 10 µg/ml (100 µl/well) can bind biotinylated mouse INHBA-His (Cat:Cat:50659-M08H), The EC50 of biotinylated mouse INHBA-His (Cat:Cat:50659-M08H) is 0.161 µg/ml.

Formulation: 140 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, 1.8 mM KH2PO4, pH7.4, 5% Mannitol, 5% Trehalose, 0.02% Tween80.

Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/ml or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Expiration Date: Expires one year from date of receipt when stored as instructed.

This protein is manufactured by Sino Biological Inc.

For Research Use Only. Not for use in diagnostic procedures.


Product Size: 50 µg
Protein Family: Growth Factors & Receptors
Research Category: Signal Transduction

Contents & storage

Includes 1 vial of protein in suspension buffer. Store at -20°C.


Manuals & protocols