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ICAM1 Recombinant Human Protein, hIgG1-Fc.His Tag

Catalog number: 10346H03H50

 Related applications: Protein Assays and Analysis

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Manufactured by Sino Biological (China); Distributed by Life Technologies.

Intercellular adhesion molecule 1 (ICAM1) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in performing cell based assays. It can also be used as a protein standard, or in other research applications.

This recombinant human protein is expressed from a DNA sequence encoding the extracellular domain of human ICAM1 (NP_000192.2) (Met 1 - Glu 480) fused to the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

N-terminal Sequence Analysis: Gln 28.

Activity: measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblasticleukemia cells. When cells are added to ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 55-65% will adhere specifically.

Formulation: lyophilized in 140 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, 1.8 mM KH2PO4, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80.

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Expiration Date: expires one year from date of receipt when stored as instructed.

ICAM1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration.ICAM1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1 / LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.

You may also be interested in the following ICAM1 products:
Primary Antibodies
Gene Expression Assays
For Research Use Only. Not for use in diagnostic procedures.


Form: Lyophilized
Purity: ≥ 90% by SDS-PAGE
Species: Human
Expression: Mammalian
Gene Symbol: ICAM1
Gene Aliases: BB2, CD54, P3.58
Product Size: 50 µg
Protein Form: Truncated, Recombinant, Cell Surface Protein
Protein Family: CD Proteins
Endotoxin Level: < 1 EU/µg
Protein Subtype: Intercellular adhesion Molecule
Molecular Weight: 100 kDa
Research Category: Immunology, Microbiology, Virology, Extracellular Matrix & Cell Adhesion
Protein Tag or Fusion: His Tag, IgG1 Fc Tag
Validated Application: Assay Standard

Contents & storage

Includes 1 vial of lyophilized protein. Store at -20 °C.


Manuals & protocols