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SPP1 Recombinant Human Protein, His Tag

Catalog number: 10352H08H250

 Related applications: Protein Assays and Analysis

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Description

Manufactured by Sino Biological (China); Distributed by Life Technologies.

Secreted Phosphoprotein 1 (SPP1) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure. In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications.

This recombinant protein is expressed from a DNA sequence encoding the pro form of human SPP1 (NP_001035147.1) (Met 1-Asn 314)fused to a polyhistidine tag at the C-terminus.

N-terminal Sequence Analysis: IIe 17.

Activity: The activity of this protein has not been tested.

Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80.

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Expiration Date: expires one year from date of receipt when stored as instructed.

Background
Secreted phosphoprotein 1, is a member of the osteopontinfamily. It is an extracellular structural protein and thereforean organic component of bone. Secreted phosphoprotein 1 is expressed in bone, although it is also expressed in other tissues. Secreted phosphoprotein 1 acts as acytokine which is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Secreted phosphoprotein 1 has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that Secreted phosphoprotein 1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia. Therefore, manipulation of plasma Secreted phosphoprotein 1 levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.

You may also be interested in the following SPP1 products:
Gene Expression Assays

Products related to SPP1 biological process:

IL-12
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Protein Family: Cell Structure⁄Organelle Proteins
Research Category: Angiogenesis, Bone Research, Cardiovascular Research, Immunology, Neurobiology, Oncology
Species: Human
Validated Application: Assay Standard
Protein Form: Full Length, Recombinant
Endotoxin Level: < 1 EU/µg
Expression: Mammalian
Form: Lyophilized
Gene Aliases: BNSP, BSPI, ETA-1, MGC110940, OPN
Gene ID: 6696
Gene Symbol: SPP1
Molecular Weight: 35 kDa
Product Line: Sino Biological®
Product Size: 5 x 50 µg
Protein Name: Secreted phosphoprotein 1
Protein Tag or Fusion: His Tag
Purification: PAGE
Purity: > 80% by SDS-PAGE
Tag Position: C-Terminal

Contents & storage

Includes 5 vials of protein in suspension buffer. Store at -20 °C..

Documents

Manuals & protocols