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IL6 Recombinant Human Protein

Catalog number: 10395HNAE50

 Related applications: Protein Assays and Analysis

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Manufactured by Sino Biological (China); Distributed by Life Technologies.

Interleukin 6 (IL-6) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications.

This recombinant protein is expressed from a DNA sequence encoding the mature form of human IL6 (NP_000591.1) (Val 30-Met 212) retaining the initial Met at the N-terminus.

N-terminal Sequence Analysis: Met.

1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL6 (100 µL/well of a 8 µg/mL solution) has been shown to bind recombinant human IL6R with a linear range of 1.25-20.0 ng/mL.
2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The EC50 for this effect is typically 0.2-0.8 ng/mL.

Formulation: lyophilized in 140 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, 1.8 mM KH2PO4, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80.

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Expiration Date: expires one year from date of receipt when stored as instructed.

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. IL-6 is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule with the molecular mass of 22 kDa-28 kDa. Three IL-6 signaling pathways (STAT1, STAT3, and Ras-dependent MAPK cascade) have been reported. Dysregulated production of IL-6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis.

You may also be interested in the following IL6 products:
Primary Antibodies
Gene Expression Assays
For Research Use Only. Not for use in diagnostic procedures.


Form: Lyophilized
Purity: ≥ 95% by SDS-PAGE
Species: Human
Expression: E. coli
Gene Symbol: IL6
Gene Aliases: BSF2, HGF, HSF, IFNB2, IL-6
Product Size: 50 µg
Protein Form: Full Length, Recombinant
Protein Family: Cytokines & Receptors
Protein Subtype: Interleukins
Molecular Weight: 20.3 kDa
Research Category: Immunology, Oncology, Inflammation
Protein Tag or Fusion: Untagged
Validated Application: Assay Standard

Contents & storage

Includes 1 vial of lyophilized protein. Store at -20 °C.


Manuals & protocols

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