Knockout™ Serum Replacement (Knockout™ SR) is for serum-free, feeder-based culture of embryonic stem cells (ESCs) and induced Pluripotent stem cells (iPSCs) from multiple species. This defined, serum-free formulation directly replaces FBS in existing protocols.
Many of the drawbacks of using FBS in stem cell culture, (differentiation of cells and heat-inactivation) can be alleviated with the use of KnockOut™ Serum Replacement. ES and iPS cells grown in KnockOut™ SR-supplemented media are substantially less differentiated than those grown in FBS-supplemented media, and germline transmission should not be compromised. With over 2000 peer-reviewed publications covering applications such as stem cell culture, differentiation, iPSC generation, ESC derivation, and transgenic modeling, KnockOut™ Serum Replacement is widely cited for stem cell culture.
Mammalian Cell Culture
Stem Cells (Embryonic)
Growth Performance Assay
cGMP for medical devices, 21 CFR Part 820 and ISO 13485
For Use With (Application)
Clinical Research, Translational Research
Purity or Quality Grade
6 to 8
Contents & Storage
Store in freezer (-5 to -20°C) and protect from light.