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TREM2 Recombinant Human Protein, His Tag

Catalog number: 11084H08H25

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Manufactured by Sino Biological (China); Distributed by Life Technologies.

Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure. In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications.

This recombinant human protein is expressed from a DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met 1-Ser 174) fused to a polyhistidine tag at the C-terminus.

N-terminal Sequence Analysis: His 19.

Activity: The activity of this protein has not been tested.

Formulation: lyophilized in PBS, pH7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80.

Reconstitution: dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Expiration Date: expires one year from date of receipt when stored as instructed.

Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing.

You may also be interested in the following TREM2 products:
Enzyme & Protein Assays
Gene Expression Assays
For Research Use Only. Not for use in diagnostic procedures.


Form: Lyophilized
Purity: ≥ 85% by SDS-PAGE
Gene ID: 54209
Species: Human
Expression: Mammalian
Gene Symbol: TREM2
Gene Aliases: TREM-2, Trem2a, Trem2b, Trem2c, TREM2
Product Size: 5 x 5 µg
Protein Form: Truncated, Recombinant
Purification: PAGE
Tag Position: C-Terminal
Protein Family: Other Proteins
Endotoxin Level: < 1 EU/µg
Protein Subtype: Other Proteins
Molecular Weight: 18.9 kDa
Research Category: Immunology, Signal Transduction
Protein Tag or Fusion: His Tag
Validated Application: Assay Standard

Contents & storage

Includes 5 vials of protein in suspension buffer. Store at -20 °C..


Manuals & protocols