Structural characterization of human S100A16, a low-affinity calcium binder.
AuthorsBabini E, Bertini I, Borsi V, Calderone V, Hu X, Luchinat C, Parigi G
JournalJ Biol Inorg Chem
PubMed ID21046186
'The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently ... More
S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors.
AuthorsMarenholz I, Heizmann CW
JournalBiochem Biophys Res Commun
PubMed ID14684152
Calcium binding proteins of the S100 family play a central role in many intra- and extracellular processes and abnormal expression was observed in various tumors and human diseases. We have identified a unique new member of this gene family: S100A16 which is the S100 protein widest distributed in human and ... More
Identification of S100A16 as a novel adipogenesis promoting factor in 3T3-L1 cells.
AuthorsLiu Y, Zhang R, Xin J, Sun Y, Li J, Wei D, Zhao AZ
JournalEndocrinology
PubMed ID21266506
S100A16 is a member of S100 protein super family that carries calcium-binding EF-hand motifs. Its expression is ubiquitous and elevated in various types of tumors. The functions of S100 proteins are still being defined, although many members of S100 protein family are traditionally considered as markers of tumor tissues. Using ... More