CD26: a negative selection marker for human Treg cells.
AuthorsSalgado FJ, Pérez-Díaz A, Villanueva NM, Lamas O, Arias P, Nogueira M,
JournalCytometry A
PubMed ID22949266
'A major obstacle hampering the therapeutic application of regulatory T (Treg) cells is the lack of suitable extracellular markers, which complicates their identification/isolation. Treg cells are normally isolated via CD25 (IL-2Ra) targeting, but this protein is also expressed by activated CD4(+) effector T (Teff) lymphocytes. Other extracellular (positive or negative) ... More
BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling.
AuthorsChaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T,
JournalEMBO J
PubMed ID23321680
'Treg activation in response to environmental cues is necessary for regulatory T cells (Tregs) to suppress inflammation, but little is known about the transcription mechanisms controlling Treg activation. We report that despite the known proinflammatory role of the chromatin-remodelling factor BRG1 in CD4 cells, deleting Brg1 in all aß T ... More
PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+)CD25(-) T cells to regulatory T-like cells.
AuthorsLiu X, Xu X, Lin X, Tian Y, Ji B, Xia S, Xu S, Yin Q, Zhang M, Jiao Z, Wang S, Xu H, Shao Q,
JournalJ Cell Biochem
PubMed ID22806628
Regulatory T cells (Tregs) are critical for maintaining self-tolerance and homeostasis, and have potential application in clinical disease therapy, such as autoimmune diseases and transplant rejection, but their numbers are limited. FOXP3 is a key transcription factor controlling Tregs development and function. Although transfection of CD4(+)CD25(-) lymphocytes with the FOXP3 ... More
Effect of IFN-beta therapy on the frequency and function of CD4(+)CD25(+) regulatory T cells and Foxp3 gene expression in relapsing-remitting multiple sclerosis (RRMS): a preliminary study.
AuthorsNamdar A, Nikbin B, Ghabaee M, Bayati A, Izad M,
JournalJ Neuroimmunol
PubMed ID19932513
Interferon-beta (IFN-beta) is an immunomodulatory drug of choice to control relapsing-remitting multiple sclerosis (RR-MS), although its function is still unclear. A reduced suppressive function of CD4(+)CD25(+) regulatory T cells (T(reg)) has been shown in RR-MS patients. In this study, to understand the effect of IFN-ss on CD4(+)CD25(+) regulatory T cells, ... More
An optimized method for the functional analysis of human regulatory T cells.
AuthorsOberg HH, Wesch D, Lenke J, Kabelitz D,
JournalScand J Immunol
PubMed ID16918705
Naturally occurring regulatory T cells (Treg) suppress the activation of antigen-responsive T cells in a cell contact-dependent manner. In order to investigate the impact of soluble mediators and receptor-ligand interactions on the interplay between naive T cells and Treg, a reproducible suppressor cell assay which functions in the absence of ... More
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.
AuthorsGuyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A,
JournalAm J Respir Crit Care Med
PubMed ID16339919
RATIONALE: T-cell responses during tuberculosis (TB) help contain Mycobacterium tuberculosis in vivo but also cause collateral damage to host tissues. Immune regulatory mechanisms may limit this immunopathology, and suppressed cellular immune responses in patients with TB suggest the presence of regulatory activity. CD4+CD25(high) regulatory T cells mediate suppressed cellular immunity ... More