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Proteintech
COX4I2 Polyclonal Antibody
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Product Details
11463-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
COX4I2 Fusion Protein Ag1987 (1-171 aa encoded by BC057779)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody was generated against full length COX4I2 protein.
Immunogen sequence: MLPRAAWSL VLRKGGGGRR GMHSSEGTTR GGGKMSPYTN CYAQRYYPMP EEPFCTELNA EEQALKEKEK GSWTQLTHAE KVALYRLQFN ETFAEMNRRS NEWKTVMGCV FFFIGFAALV IWWQRVYVFP PKPITLTDER KAQQLQRMLD MKVNPVQGLA SRWDYEKKQW KK (1-171 aa encoded by BC057779)
Target Information
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [Uniprot]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COX IV-2; Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit IV-like 2; cytochrome c oxidase, subunit 4b; cytochrome c oxidase, subunit IVb
Gene Aliases: COX4; COX4-2; COX4B; COX4I2; COX4L2; COXIV-2; dJ857M17.2
UniProt ID: (Human) Q96KJ9, (Mouse) Q91W29, (Rat) Q91Y94
Entrez Gene ID: (Human) 84701, (Mouse) 84682, (Rat) 84683
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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