The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53.
AuthorsStanhope-Baker P, Kessler PM, Li W, Agarwal ML, Williams BR,
JournalJ Biol Chem
PubMed ID15155752
'Wilms tumors are a heterogeneous class of tumors in which Wilms tumor suppressor-1 (WT1) and the p53 tumor suppressor may be variously inactivated by mutation, reduced in expression, or even overexpressed in the wild-type state. The downstream transcriptional targets of WT1 and p53 that are critical for mediating their roles ... More
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Authors Chen Fusheng; Gu YongJun; Hasegawa Hiroshi; Ruan Xueying; Arawaka Shigeki; Fraser Paul; Westaway David; Mount Howard; St George-Hyslop Peter;
JournalJ Biol Chem
PubMed ID12119298
'The presenilin 1 (PS1) and presenilin 2 (PS2) proteins are necessary for proteolytic cleavage of the amyloid precursor protein (APP) within its transmembrane domain. One of these cleavage events (termed gamma-secretase) generates the C-terminal end of the Abeta-peptide by proteolysis near residue 710 or 712 of APP(770). Another event (termed ... More
Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells.
AuthorsMunshi HG, Wu YI, Ariztia EV, Stack MS,
JournalJ Biol Chem
PubMed ID12194986
'Activation of matrix metalloproteinase 2 (MMP-2) has been shown to play a significant role in the behavior of cancer cells, affecting both migration and invasion. The activation process requires multimolecular complex formation involving pro-MMP-2, membrane type 1-MMP (MT1-MMP), and tissue inhibitor of metalloproteinases-2 (TIMP-2). Because calcium is an important regulator ... More
The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.
'TSLC1 is a tumor suppressor gene encoding a member of the immunoglobulin (Ig) superfamily. The significant homology of its extracellular domain with those of other Ig superfamily cell adhesion molecules (IgCAMs) has raised the possibility that TSLC1 participates in cell-cell interactions. In this study, the physiological properties of TSLC1 were ... More
Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes.
AuthorsVickery RG, von Zastrow M
JournalJ Cell Biol
PubMed ID9885242
'D1 and D2 dopamine receptors are structurally homologous G protein- coupled receptors that serve distinct physiological functions both in neurons and nonneural cell types. We have observed that these receptors are selectively endocytosed in HEK293 cells by distinct dynamin- dependent and -independent mechanisms. Although these endocytic mechanisms operate with similarly ... More
Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E.
AuthorsRaamsman MJ, Locker JK, de Hooge A, de Vries AA, Griffiths G, Vennema H, Rottier PJ
JournalJ Virol
PubMed ID10666264
The small envelope (E) protein has recently been shown to play an essential role in the assembly of coronaviruses. Expression studies revealed that for formation of the viral envelope, actually only the E protein and the membrane (M) protein are required. Since little is known about this generally low-abundance virion ... More
Identification of Sequence Motifs Responsible for the Adhesive Interaction between Exon v10-containing CD44 Isoforms.
Authors Hayes Gregory M.; Chiu Roland; Carpenito Carmine; Dougherty Shona T.; Dougherty Graeme J.;
JournalJ Biol Chem
PubMed ID12407110
Previous studies have demonstrated that CD44 isoforms containing the alternatively spliced exon v10 promote cell-cell adhesion via a mechanism that involves the recognition of chondroitin sulfate side chains presented on the surface of interacting cells in association with other CD44 molecules. Sequence analysis revealed the presence within exon v10 of ... More
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Authors Deng Yibin; Lin Yahong; Wu Xiangwei;
JournalGenes Dev
PubMed ID11782443
Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by mitochondria and cell death receptors. In the present study, we report that mitochondrial events are required for apoptosis induced by the cell death ligand TRAIL (TNF-related apoptosis-inducing ligand) in human cancer cells. We show that the Bax null ... More
Human macrophage activation programs induced by bacterial pathogens.
Authors Nau Gerard J; Richmond Joan F L; Schlesinger Ann; Jennings Ezra G; Lander Eric S; Young Richard A;
JournalProc Natl Acad Sci U S A
PubMed ID11805289
Understanding the response of innate immune cells to pathogens may provide insights to host defenses and the tactics used by pathogens to circumvent these defenses. We used DNA microarrays to explore the responses of human macrophages to a variety of bacteria. Macrophages responded to a broad range of bacteria with ... More
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells.
Authors Ahn Bong-Hyun; Rhim Hyangshuk; Kim Shi Yeon; Sung Young-Mo; Lee Mun-Yong; Choi Ju-Youn; Wolozin Benjamin; Chang Jong-Soo; Lee Young Han; Kwon Taeg Kyu; Chung Kwang Chul; Yoon Shin-Hee; Hahn Sang June; Kim Myung-Suk; Jo Yang-Hyeok; Min Do Sik;
JournalJ Biol Chem
PubMed ID11821392
alpha-Synuclein has been implicated in the pathogenesis of many neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the function of alpha-synuclein remains largely unknown, recent studies have demonstrated that this protein can interact with phospholipids. To address the role of alpha-synuclein in neurodegenerative disease, we have investigated whether it ... More