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Proteintech
NDUFAF2 Polyclonal Antibody
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Product Details
13891-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NDUFAF2 Fusion Protein Ag4853 (1-169 aa encoded by BC033965)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGWSQDLFR ALWRSLSREV KEHVGTDQFG NKYYYIPQYK NWRGQTIREK RIVEAANKKE VDYEAGDIPT EWEAWIRRTR KTPPTMEEIL KNEKHREEIK IKSQDFYEKE KLLSKETSEE LLPPPVQTQI KGHASAPYFG KEEPSVAPSS TGKTFQPGSW MPRDGKSHNQ (1-169 aa encoded by BC033965)
Target Information
Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B17.2-like; B17.2L; B172-like; B172L; Mimitin; mimitin, mitochondrial; MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2 isoform NDUFAF2_1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2 isoform NDUFAF2_3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2 isoform NDUFAF2_4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NDUFA12-like protein; unnamed protein product
Gene Aliases: 1810058I14Rik; B17.2L; C86051; MC1DN10; mimitin; MMTN; NDUFA12L; NDUFAF2
UniProt ID: (Human) Q8N183, (Mouse) Q59J78
Entrez Gene ID: (Human) 91942, (Mouse) 75597
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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