CaptureSelect™ C1-inhibitor Affinity Matrix

Catalog number:  194340050

Thermo Scientific™  Related applications: Chromatography

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CaptureSelect™ C1-inhibitor Affinity Matrix is intended for the purification of human C1 esterase inhibitor from recombinant as well as plasma/serum sources.

• Efficient purification of C1 esterase inhibitor with high yields and retained activity
• Excellent scalability
• Non-animal derived

CaptureSelect C1-inhibitor Affinity Matrix binds human C1 esterase inhibitor from recombinant and plasma/serum sources. C1 esterase inhibitor is a protease inhibitor belonging to the serpin superfamily that inhibits the complement system to prevent spontaneous activation. The high selectivity and yields obtained using C1-inhibitor Affinity Matrix enable a robust and efficient purification process with excellent purity in one step.

Free of animal components
Thermo Fisher Scientific CaptureSelect products are affinity ligands created by a proprietary technology based on camelid-derived single-domain antibody fragments. The ligand is a 13-kDa single-domain fragment that comprises the 3 CDRs that form the antigen binding domain and is efficiently produced by the yeast Saccharomyces cerevisiae in a production process free of animal components.

Main characteristics:

Matrix: Agarose based, aldehyde activated
Average particle size: 65 ± 10 µm
Ligand: CaptureSelect C1-inhibitor affinity ligand
Ligand coupling method: Aldehyde coupling via NH2 residues of the ligand
Binding capacity: ~5 mg/mL resin (determined with human plasma)
Elution conditions: 20 mM Tris, 2.0 M MgCl2, pH 7; 20 mM Citric acid, pH 3.0
Flow characteristics: 100-200 cm/h (up to 1 bar)
Formulation buffer: 20% (v/v) ethanol
For Research Use Only. Not for use in diagnostic procedures.


Column Type: Agarose Resin
Immobilized Phase: Anti-C1 inhibitor
Product Line: CaptureSelect™
Product Size: 50 mL

Contents & storage

Store in refrigerator (2–8°C).


Manuals & protocols

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