DMA (dimethyl adipimidate)

Catalog number: 20660

Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

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Thermo Scientific Pierce DMA is dimethyl adipimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 6-atom spacer arm.

Features of dimethyl adipimidate:

Reactive groups: imidoester (both ends)
Reactive towards: amino groups (primary amines)
• Shortest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins

Product References
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
DMP (dimethyl pimelimidate)
DMS (dimethyl suberimidate)
DTBP (Wang and Richard's Reagent)
For Research Use Only. Not for use in diagnostic procedures.


Spacer: Short
Solubility: Water
Product Size: 1 g
Labeling Method: Chemical Labeling
Crosslinker Type: Homobifunctional

Contents & storage

Store desiccated at 4°C. Shipped at ambient temperature.


Manuals & protocols