Search
Element Search
Structure Search
Thermo Scientific Chemicals
L(+)-Amethopterin hydrate, 99%
L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol
Have Questions?
Change view
Catalog number 208105000
Price (EUR)
392,70
Online Exclusive
462,00Save 69,30 (15%)
Each
Quantity:
500 mg
Packaging:
Glass Bottle
Price (EUR)
392,70
Online Exclusive
462,00Save 69,30 (15%)
Each
Chemical Identifiers
CAS133073-73-1
IUPAC Name(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Molecular FormulaC20H22N8O5
InChI KeyFBOZXECLQNJBKD-UGPWUYPHNA-N
SMILESCN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
View more
Specifications
Specification Sheet
Specification SheetInfrared spectrumConforms
Specific optical rotationon anhydrous substance
Water=<13 % (K.F.)
Appearance (Color)Yellow to orange
HPLC>=98.5 %
View more
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
- It has tumoricidal activity
Applications
- L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
- It can be used in anti-tumor studies
- It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
- It can also inhibit production of pro-inflammatory cytokines
RUO – Research Use Only
General References:
- Friedman, B.; Cronstein, B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019, 86(3), 301-307.
- Sasso, S.P.; Gilli, R.M.; Sari, J.C.; Rimet, O.S.; Briand, C.M. Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochim Biophys Acta. 1994, 20, 1207(1), 74-9.
- Pittman, S.M.; Strickland, D.; Ireland, C.M. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994, 215 (2), 263-72.