Thermo Scientific Pierce Sulfo-KMUS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (16.3 angstroms).
Features of Sulfo-KMUS:
•
Reactive groups: sulfo-NHS ester and
maleimide•
Reactive toward: amino and sulfhydryl groups
• Long aliphatic spacer arm compared to
Sulfo-GMBS• Sulfo-NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
• Non-cleavable
• Water-soluble
Product References:Crosslinker Application Guide -- search for recent literature references for this product
