Aldosterone, 98%

Name: Aldosterone, 98%
SKU: 215360050

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

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Catalog number 215360050

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Chemical Identifiers

CAS52-39-1

IUPAC Name(1S,3aS,3bS,9aR,9bS,10S,11aR)-10-hydroxy-1-(2-hydroxyacetyl)-9a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-11a-carbaldehyde

Molecular FormulaC21H28O5

InChI KeyPQSUYGKTWSAVDQ-ZVIOFETBSA-N

SMILESC[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)[C@H]21)C=O

Specifications

Specification Sheet

Specific optical rotation+150° to +162° (20°C, 589 nm) (c=0.1, CHCl3)

Appearance (Color)White to light yellow

HPLC>=97.5 %

Appearance (Form)Powder

Infrared spectrumConforms

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)

It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure

In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes

Aldosterone has been used in combination with salt to induce renal injury in mice

It is used to stimulate primary liver sinusoidal endothelial cells

RUO – Research Use Only

Literature References

Zhu, J.J.; Chen, Y.P.; Yang, M., Liu, B.L.; Dong, J.; Dong, H.R.; Rui, H.L.; Cheng, H. Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes. Mol Med Rep. 2018, 17, (3), 4589-4598.

Luo, X.; Dan, W.; Luo, X.; Zhu, X.; Wang, G.; Ning, Z., Li, Y.; Ma, X., Yang, R.; Jin, S.; Huang, Y.; Meng, Y.; Li, X. Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration. Redox Biol. 2017, 13, 508-521.

Briet, M.; Schiffrin, E. Aldosterone: effects on the kidney and cardiovascular system. Nature Reviews Nephrology. 2010, 6, 261–273.