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Aldosterone, 98%
Aldosterone, 98%
Aldosterone, 98%
Thermo Scientific Chemicals

Aldosterone, 98%

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.
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製品番号（カタログ番号）数量パッケージ
21536025025 mgGlass bottle
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製品番号（カタログ番号） 215360250
価格（JPY）
-
数量:
25 mg
パッケージ:
Glass bottle
一括またはカスタム形式をリクエストする
化学物質識別子
CAS52-39-1
IUPAC Name(1S,3aS,3bS,9aR,9bS,10S,11aR)-10-hydroxy-1-(2-hydroxyacetyl)-9a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-11a-carbaldehyde
Molecular FormulaC21H28O5
InChI KeyPQSUYGKTWSAVDQ-ZVIOFETBSA-N
SMILESC[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)[C@H]21)C=O
さらに表示
仕様Specification Sheetスペックシート
Specific optical rotation+150° to +162° (20°C, 589 nm) (c=0.1, CHCl3)
Appearance (Color)White to light yellow
HPLC>=97.5 %
Appearance (Form)Powder
Infrared spectrumConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)
  • It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

  • Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure
  • In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes
  • Aldosterone has been used in combination with salt to induce renal injury in mice
  • It is used to stimulate primary liver sinusoidal endothelial cells
RUO – Research Use Only

General References:

  1. Zhu, J.J.; Chen, Y.P.; Yang, M., Liu, B.L.; Dong, J.; Dong, H.R.; Rui, H.L.; Cheng, H. Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes. Mol Med Rep. 2018, 17, (3), 4589-4598.
  2. Luo, X.; Dan, W.; Luo, X.; Zhu, X.; Wang, G.; Ning, Z., Li, Y.; Ma, X., Yang, R.; Jin, S.; Huang, Y.; Meng, Y.; Li, X. Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration. Redox Biol. 2017, 13, 508-521.
  3. Briet, M.; Schiffrin, E. Aldosterone: effects on the kidney and cardiovascular system. Nature Reviews Nephrology. 2010, 6, 261–273.