Thermo Scientific™

SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)

Catalog number:  21558

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Features of SMPT:

Reactive groups: NHS ester and pyridyldithiol
Reactive towards: amino and sulfhydryl groups
• Cleavable with disulfide reducing agents
• Water-insoluble (dissolve first in DMF or DMSO)
• Contains a hindered disulfide bond; has formed immunotoxins with improved stability
• In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
• Compare to other varieties of SPDP-type reagents, including pegylated forms

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Heterobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 50 mg
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Spacer: Cleavable, Mid-Length

Contents & storage

Upon receipt store desiccated at -20°C. Product is shipped at ambient temperature.


Manuals & protocols