Thermo Scientific™

BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Catalog number: 21581
Thermo Scientific™

BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Catalog number: 21581
Catalog Number
21581
Unit Size
100 mg
Price (USD)
342.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
10 x 1 mg
Price (USD)
245.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
21581100 mg
342.00
Your Price:
***
A3539610 x 1 mg
245.00
Your Price:
***
Product Overview
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Additional Information
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BS(PEG)5 is a bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (—NH2) in proteins and other molecules. The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.

Thermo Scientific No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.

Features of BS(PEG)5:

Reactive groups: sulfo-NHS ester (both ends)
Reactive towards: amino groups (primary amines)
• NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
• Water-soluble; compare to non-pegylated BS3 (also soluble) and DSS (water-insoluble)
• Membrane-impermeable, allowing for cell surface labeling
• Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
• Polyethylene glycol spacer arms help maintain conjugate solubility
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Ideal for small molecule or peptide conjugations

Alternative Names for BS(PEG)n:

• Bis-NHS-dPEG
• NHS-PEG-NHS
• BS(PEO)5
• Bis(NHS)PEO5
• BS-PEO9
• dPEG NHS ester
• Bis-succinimide ester PEG 400

Product References
Crosslinker Application Guide -- search for recent literature references for this product
Bioconjugate Techniques, Academic Press (Part No. 20036)

Related Products
BS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate)
BS3 (bis(sulfosuccinimidyl)suberate)
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Description
Pierce BS(PEG)5
Product Line
Pierce™
Labeling Method
Chemical Labeling
Crosslinker Type
Homobifunctional
Reactive Moiety
NHS Ester
Spacer
Extra-Long, Pegylated
Form
Liquid
Quantity
100 mg
Type
Crosslinker
Solubility
Water

Contents & Storage

Store desiccated at -20°C. Shipped at ambient temperature.

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