BS3 (bis(sulfosuccinimidyl)suberate), No-Weigh™ Format - FAQs

What is the difference between DSS and BS3 crosslinkers?

BS3 is the water-soluble analogue of DSS (i.e., DSS is the membrane-permeable analog of BS3). DSS is water-insoluble and membrane-permeable, so it can be used for both intracellular and cell surface crosslinking. BS3 is water-soluble and membrane-impermeable, so it can be used for cell-surface crosslinking.

Find additional tips, troubleshooting help, and resources within our Protein Assays and Analysis Support Center.