Thermo Scientific™

MPBH (4-(4-N-maleimidophenyl)butyric acid hydrazide)

Catalog number: 22305
Thermo Scientific™

MPBH (4-(4-N-maleimidophenyl)butyric acid hydrazide)

Catalog number: 22305
Catalog Number
22305
Unit Size
50 mg
Price (USD)
Price: 444.00
Your price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
2230550 mg
Price: 444.00
Your price:
-
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Thermo Scientific Pierce MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Features of MPBH:

Reactive groups: maleimide and hydrazide
Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
• Long (17.9A), sulfhydryl-to-aldehyde crosslinker with an aromatic ring in its spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
• Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMPH
EMCH
KMUH
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Chemical Reactivity
Carbohydrate-Sulfhydryl
Cleavable
No
Description
MPBH
Molecular Weight (g/mol)
309.75
PEGylated
No
Spacer Arm Length
17.9 Å
Cell Permeability
Yes
Shipping Condition
Ambient
Product Line
Pierce™
Labeling Method
Chemical Labeling
Crosslinker Type
Heterobifunctional
Reactive Moiety
Amine, Hydrazide, Maleimide
Spacer
Medium (10 to 30 Å)
Form
Powder
Quantity
50 mg
Solubility
DMF, DMSO
Format
Standard
Water Soluble
No
Product Type
Crosslinker

Contents & Storage

Upon receipt store desiccated at 4°C.

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