Thermo Scientific™

DTME (dithiobismaleimidoethane)

Catalog number:  22335

 Related applications: Protein Labeling & Crosslinking

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Thermo Scientific Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.

Features of DTME:

Reactive groups: maleimide (both ends)
Reactive towards: sulfhydryl groups
• Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
• Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
• Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMH (bismaleimidohexane)
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Homobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 50 mg
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Spacer: Cleavable, Long

Contents & storage

Store desiccated at 4°C. Shipped at ambient temperature.


Manuals & protocols

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