DTME (dithiobismaleimidoethane)

Catalog number: 22335

Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Your price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}}
also known as {{product.formattedSku}} 
{{subscriptionDetails.selectedRatePlan.billingPeriod}} {{subscriptionDetails.selectedRatePlan.billingPeriod}} {{product.availability.message}}
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top


Thermo Scientific Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.

Features of DTME:

Reactive groups: maleimide (both ends)
Reactive towards: sulfhydryl groups
• Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
• Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
• Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMH (bismaleimidohexane)
For Research Use Only. Not for use in diagnostic procedures.


Spacer: Long, Cleavable
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Product Size: 50 mg
Labeling Method: Chemical Labeling
Crosslinker Type: Homobifunctional

Contents & storage

Store desiccated at 4°C. Shipped at ambient temperature.


Manuals & protocols