Thermo Scientific Pierce SMPB is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length aromatic spacer arm (11.6 angstroms).
Features of SMPB:
• Reactive groups: NHS ester and maleimide • Reactive towards: amino and sulfhydryl groups • Extended chain analog of MBS • Non-cleavable • Water-insoluble (dissolve first in DMF or DMSO) • Conjugates formed with SMPB are more stable in serum than SPDP conjugates
Product References: Crosslinker Application Guide -- search for recent literature references for this product