CL(PEG)12 Carboxy-PEG-Lipoamide Compound

Catalog number: 26135

Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

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Description

Thermo Scientific Pierce CL(PEG)12, or carboxy-PEG12-lipoamide, is a carboxyl- and bidentate thiol-terminated compound that contains a 4-unit polyethylene glycol (PEG) spacer and is used to modify quantum dots, and silver or gold surfaces and particles.

CL(PEG)12 is a bidentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate "handles" for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides.

Features of carboxy-PEG12-lipoamide:

Metal-binding—terminal bidentate thiol reacts spontaneously with silver, gold and other metal surfaces to form strong dative bonds
Carboxylate—terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry
Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
Spacer arm—12-unit PEG spacer makes the reagent nearly 56 angstroms long, minimizing steric hindrance for protein immobilization and binding assays

The use of CL(PEG)12 with ML(PEG)4 in surface modification can form a hydrophilic "lawn" of methyl ether-terminated PEGs with periodic exposed carboxy -containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Typical PEG reagents contain heterogeneous mixtures of different PEG chain lengths; however, our PEG reagents are homogenous compounds of defined molecular weight and spacer length, providing precision in optimizing modification applications.

Related Products
CT(PEG)12 Carboxy-PEG-Thiol Compound
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Product Size: 100 mg
Chemical Reactivity: Metal Surface

Contents & storage

Store at 4°C protected from moisture. Shipped at ambient temperature.

Documents

Manuals & protocols