Thermo Scientific Chemicals

Hydroxychloroquine sulfate, 98%, Thermo Scientific Chemicals

Catalog number: 263010250
25 g, Glass bottle, Each
Thermo Scientific Chemicals

Hydroxychloroquine sulfate, 98%, Thermo Scientific Chemicals

Catalog number: 263010250
25 g, Glass bottle, Each
Quantity
Packaging

Chemical Identifiers

CAS
747-36-4
IUPAC Name
2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; sulfuric acid
Molecular Formula
C18H28ClN3O5S
InChI Key
JCBIVZZPXRZKTI-UHFFFAOYNA-N
SMILES
OS(O)(=O)=O.CCN(CCO)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
UV spectrophotometry
>=97.5 % (on dried basis)
Sulfated ash
=<0.2 %
Appearance (Color)
White to off-white
Appearance (Form)
Crystalline powder
Loss on drying
=<2 % (105°C, 2 h)

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hydroxychloroquine sulfate shows antimalarial activity against malaria parasites mainly in the intra-erythrocytic phase of its life cycle. It acts by inhibiting the heme polymerase inside the food vacuole of the parasites
  • It shows an inhibitory activity in autophagy preventing the lysosome fusion with the autophagosome
  • Some studies demonstrated that hydroxychloroquine sulfate, due to its antiviral activity can restrict HIV infection in vitro

Applications

  • Hydroxychloroquine sulfate displays antiviral and anti-rheumatic activities
  • In vitro and in vivo experiments have been performed to investigate the role of hydroxychloroquine sulfate in the treatment of SARS-CoV-2 disease
  • Hydroxychloroquine sulfate can be used in immunofluorescence assays to evaluate the antiviral mechanisms in dengue virus-2 infection. In this disease, this compound can activate the innate immune response
RUO – Research Use Only

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