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Proteintech
Cyclin D3 Polyclonal Antibody
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Product Details
26755-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cyclin D3 Fusion Protein Ag25151 (250-292 aa encoded by BC011616)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ALRESLREA SQTSSSPAPK APRGSSSQGP SQTSTPTDVT AIHL (250-292 aa encoded by B C011616)
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CCND 3; CCND3; CGD3; CyclinD3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3; unnamed protein product
Gene Aliases: CCND3
UniProt ID: (Human) P30281, (Rat) P48961
Entrez Gene ID: (Human) 896, (Rat) 25193
cyclin-dependent protein serine/threonine kinase activity
protein binding
cyclin-dependent protein serine/threonine kinase regulator activity
protein kinase binding
protein serine/threonine kinase activator activity
cyclin-dependent protein serine/threonine kinase activator activity
kinase activator
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
signal transduction
T cell proliferation
regulation of cell proliferation
cell division
regulation of cell cycle
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of protein phosphorylation
protein phosphorylation
positive regulation of cell proliferation
response to glucose
response to organic substance
hyaluronan biosynthetic process
response to peptide hormone
positive regulation of cyclin-dependent protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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