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Proteintech
NaPi-IIa Polyclonal Antibody
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Product Details
26783-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NaPi-IIa fusion protein Ag24807
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Amount
112.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MLSYGERLGS PAVSPLPVRG GHVMRGTAFA YVPSPQVLHR IPGTSAYAFP SLGPVALAEH TCPCGEVLER HEPLPAKLAL EEEQKPESRL VPKLRQAGAM LLK
Target Information
Renal tubular reabsorption of phosphate is critical to the maintenance of phosphate homeostasis in mammals. The brush-border membrane Na+/Pi cotransport systems in proximal tubules play a major role in this process. The renal Na(+)/P(i) cotransporter NPT2 is expressed in the brush border membrane (BBM) of proximal tubular cells. NPT2 gene expression is crucial for PTH effects on renal P(i) handling. However, renal expression of the sodium/phosphate cotransporter gene, NPT2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. NPT2 is an integral membrane protein expressed in kidney and lung. The gene encoding human NPT1 maps to chromosome 6q21.3-p23, while the gene encoding human NPT2 maps to chromosome 5q35.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; Na/Pi cotransporter; naPi-2a; NaPi-3; naPi-7; renal Na+/Pi transporter; renal sodium-dependent phosphate transporter; Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; Sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 17 (sodium/hydrogen exchanger) member 2; solute carrier family 17 (sodium/hydrogen exchanger), member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; Solute carrier family 34 member 1; solute carrier family 34, member 1; type IIa Na+/Pi-cotransporter; unnamed protein product
Gene Aliases: FRTS2; HCINF2; NaPi-2; NAPI-3; NaPi-IIa; NaPi2A; NPHLOP1; NPT2; Npt2a; NPTIIa; SLC11; SLC17A2; SLC34A1
UniProt ID: (Human) Q06495, (Rat) Q06496
Entrez Gene ID: (Human) 6569, (Mouse) 20505, (Rat) 25548
ossification
kidney development
ion transport
sodium ion transport
phosphate ion transport
response to nutrient
glycoprotein metabolic process
response to xenobiotic stimulus
response to lead ion
cellular response to phosphate starvation
cellular phosphate ion homeostasis
response to magnesium ion
response to estradiol
response to vitamin A
phosphate ion transmembrane transport
response to potassium ion
indole metabolic process
response to peptide hormone
sodium-dependent phosphate transport
positive regulation of membrane potential
response to cadmium ion
response to mercury ion
phosphate ion homeostasis
response to growth hormone
response to parathyroid hormone
cellular response to metal ion
cellular response to parathyroid hormone stimulus
tricarboxylic acid metabolic process
cellular response to staurosporine
response to thyroid hormone
dentinogenesis
sodium ion import across plasma membrane
gentamycin metabolic process
response to peptide
arsenate ion transmembrane transport
positive regulation of sodium-dependent phosphate transport
positive regulation of phosphate transmembrane transport
transport
bone remodeling
protein homooligomerization
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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