2'-OMe-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.
Features: • Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite • Molecular formula—C40H56N7O9P • Base—U • Formula weight—760.8 g/mol • CAS number—110764-79-9 • HPLC purity—≥99%; M-11 Impurity: ≤0.01%; Single critical impurity ≤0.3% • 31P NMR purity—>99%; Sum of non-primary peaks at 140-152ppm ≤0.5%
For Research Use Only. Not for use in diagnostic procedures.