Thermo Scientific™

TMEA (tris(2-maleimidoethyl)amine)

Catalog number:  33043

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce TMEA is a trifunctional crosslinker containing three reactive maleimide groups to enable three-way conjugation and polymerization of sulfhydryl-containing molecules.

Features of Thermo Scientific Pierce TMEA:

• Reactive groups: maleimide (on three termini)
• Reactive towards: sulfhydryl groups
• 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine, composed of three maleimide groups on short spacer arms
• Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
• Noncleavable
• Useful for the preparation of trimeric complexes of cysteine-containing peptides and other sulfhydryl-containing compounds
• Core molecule for the construction of dendritic polymers

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMH (bismaleimidohexane)
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Homotrifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 50 mg
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Spacer: Mid-Length

Contents & storage

Storage: Store product at 4°C protected from moisture. Product is shipped at ambient temperature.


Manuals & protocols