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Thermo Scientific Chemicals
Hydrocortisone, 98%
Hydrocortisone, CAS # 50-23-7, is the pharmaceutical formulation of the hormone, cortisol, and is commonly administered as an immunosuppressive drug.
化学物質識別子
CAS50-23-7
IUPAC Name(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Molecular FormulaC21H30O5
InChI KeyJYGXADMDTFJGBT-VWUMJDOOSA-N
SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
さらに表示
仕様
スペックシート
スペックシートAppearance (Form)Powder
Infrared spectrumConforms
HPLC>=97.5 %
Melting point212°C to 217°C
Specific optical rotation+150° to +156° (20°C, 589 nm) (C=1, dioxane)
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Hydrocortisone is the synthetic formulation of the naturally occurring hormone, cortisol
• It is available as a white crystalline powder soluble in water, DMSO, and ethanol
• It is stable at room temperature but sensitive to light, and reactive in the presence of strong oxidizing agents
Applications
• Hydrocortisone works as an agonist to glucocorticoid receptors, thereby suppressing the inflammatory response of the immune system
• It’s administration induces gluconeogenesis, thus increasing endogenous blood sugar levels
• Research indicates a role for hydrocortisone in the metabolism of fat, protein, and carbohydrates
RUO – Research Use Only
Literature References
Ramamoorthy, S. and Cidlowski, J. A. Corticosteroids-Mechanisms of Action in Health and Disease. Rheum Dis Clin North Am. 2016, 42(1): 15–31.
Spireas, S.; Sadu, S.; and Grover, R. In vitro release evaluation of hydrocortisone liquisolid tablets. Journal of Pharmaceutical Sciences. 1998, 87(7), 867-872.
Oji, N. and Shreeve, W. W. Acute effects of hydrocortisone on gluconeogenesis from 14C- and 3H-labeled substrates in intact rats Endocrinology. 1967, 80(6), 1062-8.
Dandona. P; Thusu, K.; Hafeez, R.; Abdel-Rahman, E. Effect of hydrocortisone on oxygen free radical generation by mononuclear cells. Metabolism. 1998, 47(7), 788-791.