Thermo Scientific™

Pierce™ Iodoacetic Acid

Catalog number:  35603

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce Iodoacetic Acid (IAA) can react with several protein functional groups but is typically used for specific S-carboxymethylation of sulfhydryls (reduced cysteines).

Features of Pierce Iodocetic Acid (IAA):

• React at slightly alkaline pH for specific S-carboxymethylation of free sulfhydryls
• React at low pH for specific carboxymethylation of methionines
• React at high pH to favor carboxymethylation of histidines and lysines
• Methylate reduced cysteine peptide fragments in protease digests for mass spectrometry

Iodoacetic acid reacts with sulfhydryls on cysteines, imidazolyl side chain nitrogens of histidines, the thioether of methionine and the primary amine group of lysines.The rate of reaction and specificity is dependent on the ionization level, which can be manipulated by the pH of the reaction condition.

Related Products
Pierce™ Iodoacetamide, Single-Use
For Research Use Only. Not for use in diagnostic procedures.



Chemical Reactivity: Thiol
Label or Dye: Unreactive Group
Product Line: Pierce™
Product Size: 500 mg
Solubility: Water
Spacer: Short

Contents & storage

Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, between the following temperatures: 2 to 8°C.


Manuals & protocols