Induction of pluripotent stem cells from human third molar mesenchymal stromal cells.
AuthorsOda Y, Yoshimura Y, Ohnishi H, Tadokoro M, Katsube Y, Sasao M, Kubo Y, Hattori K, Saito S, Horimoto K, Yuba S, Ohgushi H
JournalJ Biol Chem
PubMed ID20595386
The expression of four transcription factors (OCT3/4, SOX2, KLF4, and MYC) can reprogram mouse as well as human somatic cells to induced pluripotent stem (iPS) cells. We generated iPS cells from mesenchymal stromal cells (MSCs) derived from human third molars (wisdom teeth) by retroviral transduction of OCT3/4, SOX2, and KLF4 ... More
Pseudomonas aeruginosa Affects Airway Epithelial Response and Barrier Function During Rhinovirus Infection.
AuthorsEndres A,Hügel C,Boland H,Hogardt M,Schubert R,Jonigk D,Braubach P,Rohde G,Bellinghausen C
JournalFrontiers in cellular and infection microbiology
PubMed ID35265536
Cystic fibrosis (CF) lung disease is aggravated by recurrent and ultimately chronic bacterial infections. One of the key pathogens in adult CF lung disease is P. aeruginosa (PA). In addition to bacteria, respiratory viral infections are suggested to trigger pulmonary exacerbations in CF. To date, little is known on how ... More
IL-17A induces chromatin remodeling promoting IL-8 release in bronchial epithelial cells: Effect of Tiotropium.
BACKGROUND: Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal adenocarcinoma (PDAC), as over 85% experience SMW, which is responsible for ~30% of patient deaths. While the established ... More
Expression of fibroblast growth factor 23 by canine soft tissue sarcomas.
AuthorsHardcastle MR,Dittmer KE
JournalVeterinary and comparative oncology
PubMed ID24923416
Transcriptomics provides insight into Mytilus galloprovincialis (Mollusca: Bivalvia) mantle function and its role in biomineralisation.
Identification of Fusarium oxysporum f. sp. lactucae Race 1 as the Causal Agent of Lettuce Fusarium Wilt in Greece, Commercial Cultivars' Susceptibility, and Temporal Expression of Defense-Related Genes.
AuthorsTziros GT,Karaoglanidis GS
JournalMicroorganisms
PubMed ID37110505
Fusarium wilt of lettuce is found throughout the world, causing significant yield losses. Lettuce is the most-cultivated leafy vegetable in Greece, affected by a large number of foliar and soil-borne pathogens. In this study, 84 isolates of Fusarium oxysporum, obtained from soil-grown lettuce plants exhibiting wilt symptoms, were characterized as belonging ... More
Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent.
OBJECTIVE: African ancestry seems to be a risk factor for hypertension; however, few genetic studies have addressed this issue. This study aimed to investigate the prevalence of polymorphisms NOS3; rs1799983, IGFBP3; rs11977526 and TCF7L2; rs7903146 in Brazilian women of African descent and their association with hypertension. RESULTS: The prevalences of ... More
Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing.
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
PubMed ID33051351
Abnormalities in interactions between sensory neurons and Schwann cells (SCs) may result in heightened pain processing and chronic pain states. We previously reported that SCs express the NMDA receptor (NMDA-R), which activates cell signaling in response to glutamate and specific protein ligands, such as tissue-type plasminogen activator. Herein, we genetically ... More
Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained debilitating fatigue, cognitive dysfunction, gastrointestinal disturbances, and orthostatic intolerance. Here, we report a multi-omic analysis of a geographically diverse cohort of 106 cases and 91 healthy controls that revealed differences in gut microbiome diversity, abundances, functional pathways, and interactions. Faecalibacterium prausnitzii ... More
Anemonin improves intestinal barrier restoration and influences TGF-β1 and EGFR signaling pathways in LPS-challenged piglets.
AuthorsXiao K,Cao ST,Jiao le F,Lin FH,Wang L,Hu CH
JournalInnate immunity
PubMed ID27189428
Variation in Human Milk Composition Is Related to Differences in Milk and Infant Fecal Microbial Communities.
Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these ... More
NF-κB controls four genes encoding core enzymes of tricarboxylic acid cycle.
AuthorsZhou F,Xu X,Wu J,Wang D,Wang J
JournalGene
PubMed ID28400269
Suspended particles phoD alkaline phosphatase gene diversity in large shallow eutrophic Lake Taihu.
AuthorsZhang T,Qin M,Wei C,Li D,Lu X,Zhang L
JournalThe Science of the total environment
PubMed ID32348945
Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans.
AuthorsShi YC,Pan TM,Liao VH
JournalJournal of agricultural and food chemistry
PubMed ID27554775
PEP-1-GRX-1 Modulates Matrix Metalloproteinase-13 and Nitric Oxide Expression of Human Articular Chondrocytes.
AuthorsHwang HS,Park IY,Kim HA,Choi SY
JournalCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
PubMed ID28214840
Characterization of an Alpha Type Carbonic Anhydrase from Paracentrotus lividus Sea Urchin Embryos.
AuthorsKarakostis K,Costa C,Zito F,Brümmer F,Matranga V
JournalMarine biotechnology (New York, N.Y.)
PubMed ID27230618
LINC01980 facilitates esophageal squamous cell carcinoma progression via regulation of miR-190a-5p/MYO5A pathway.
AuthorsLiang X,Wu Z,Shen S,Niu Y,Guo Y,Liang J,Guo W
JournalArchives of biochemistry and biophysics
PubMed ID32325088
PA-seq for Global Identification of RNA Polyadenylation Sites of Kaposi's Sarcoma-Associated Herpesvirus Transcripts.
AuthorsNi T,Majerciak V,Zheng ZM,Zhu J
JournalCurrent protocols in microbiology
PubMed ID27153384
Kaposi sarcoma-associated herpesvirus (KSHV) is a human oncovirus linked to the development of several malignancies in immunocompromised patients. Like other herpesviruses, KSHV has a large DNA genome encoding more than 100 distinct gene products. Despite being transcribed and processed by cellular machinery, the structure and organization of KSHV genes in ... More
Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma.
AuthorsSaito-Sasaki N,Sawada Y,Okada E,Nakamura M
JournalDiagnostics (Basel, Switzerland)
PubMed ID34064472
Cell adhesion molecular 1 (CADM1) is a multifunctional cell adhesion molecule belonging to the immunoglobulin superfamily, which suppresses malignant solid tumor development. However, the correlation between CADM1 expression and prognosis in cutaneous squamous cell carcinoma (cSCC) patients remains unclear. In a retrospective analysis of 88 patients diagnosed with cSCC at ... More
Partial duplication of the CRYBB1-CRYBA4 locus is associated with autosomal dominant congenital cataract.
Congenital cataract is a rare but severe paediatric visual impediment, often caused by variants in one of several crystallin genes that produce the bulk of structural proteins in the lens. Here we describe a pedigree with autosomal dominant isolated congenital cataract and linkage to the crystallin gene cluster on chromosome ... More
HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer.
AuthorsHart V,Silipo M,Satam S,Gautrey H,Kirby J,Tyson-Capper A
JournalJournal of cancer research and clinical oncology
PubMed ID34136934
In this study, two novel alternative splice variants of HER2, named HER2-PI9 and HER2-I12, were identified in breast cancer cell lines and breast tumour tissues. Whilst HER2-P19 arises from the inclusion of an 117Â bp cassette-exon of intron 9 of HER2, HER2-I12 results from intron 12 inclusion. In silico analyses were ... More
Progesterone-induced amplification and advancement of GnRH/LH surges are associated with changes in kisspeptin system in preoptic area of estradiol-primed female rats.
AuthorsLeite CM,Kalil B,Uchôa ET,Antunes-Rodrigues J,Elias LK,Levine JE,Anselmo-Franci JA
JournalBrain research
PubMed ID27566061
Molecular detection of infection homogeneity and impact of miltefosine treatment in a Syrian golden hamster model of Leishmania donovani and L. infantum visceral leishmaniasis.
AuthorsEberhardt E,Mondelaers A,Hendrickx S,Van den Kerkhof M,Maes L,Caljon G
JournalParasitology research
PubMed ID27412759
Assessment of Sugar Components and Genes Involved in the Regulation of Sucrose Accumulation in Peach Fruit.
Pravastatin attenuates the action of the ETS domain-containing protein ELK1 to prevent atherosclerosis in apolipoprotein E-knockout mice via modulation of extracellular signal-regulated kinase 1/2 signal pathway.
AuthorsYan W,Li D,Zhou X
JournalClinical and experimental pharmacology & physiology
PubMed ID27998006
The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice.
AuthorsGuo ZH,Haslam RP,Michaelson LV,Yeung EC,Lung SC,Napier JA,Chye ML
JournalThe Plant journal : for cell and molecular biology
PubMed ID31437323
Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease.
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
PubMed ID37096392
BACKGROUND: The roles of hypoxia and hypoxia inducible factor (HIF) during chronic kidney disease (CKD) are much debated. Interventional studies with HIF-α activation in rodents have yielded contradictory results. The HIF pathway is regulated by prolyl and asparaginyl hydroxylases. While prolyl hydroxylase inhibition is a well-known method to stabilize HIF-α, ... More
Defining the combined stress response in wild Arachis.
Nematodes and drought are major constraints in tropical agriculture and often occur simultaneously. Plant responses to these stresses are complex and require crosstalk between biotic and abiotic signaling pathways. In this study, we explored the transcriptome data of wild Arachis species subjected to drought (A-metaDEG) and the root-knot nematode Meloidogyne ... More
Greenhouse test of spraying dsRNA to control the western flower thrips, Frankliniella occidentalis, infesting hot peppers.
AuthorsKhan F,Kim M,Kim Y
JournalBMC biotechnology
PubMed ID37016358
BACKGROUND: The western flower thrips Frankliniella occidentalis is an insect pest that damages various crops, including hot peppers. It is a vector of a plant pathogen, tomato spotted wilt virus. To control this pest, chemical insecticides have been used in the past, but the control efficacy is unsatisfactory owing to ... More
Magnesium inhibits the calcification of the extracellular matrix in tendon-derived stem cells via the ATP-P2R and mitochondrial pathways.
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring accelerating development of prophylactic and therapeutic interventions. Molecular understanding of neutralizing antibodies (NAbs) would greatly help advance the development of monoclonal antibody (mAb) therapy, as well ... More
Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells.
AuthorsAhn S,Kim E,Lee K,Lee DC
JournalInternational immunopharmacology
PubMed ID27344640
The CYP2B6 G516T polymorphism influences CD4(+) T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon.
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
PubMed ID27940179
Effect of natural compounds on Fusarium graminearum complex.
AuthorsHeidtmann-Bemvenuti R,Tralamazza SM,Jorge Ferreira CF,Corrêa B,Badiale-Furlong E
JournalJournal of the science of food and agriculture
PubMed ID26699689
Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles.
Thrombosis is a key pathological event in cardiovascular diseases and is also the most important targeting process for their clinical management. In this study, arachidonic acid (AA) was used to induce thrombus formation in zebrafish larvae. Blood flow, red blood cell (RBCs) aggregation and cellular oxidative stress were measured to ... More
Suppressive effects of dehydrocostus lactone on the toll-like receptor signaling pathways.
Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.
AuthorsGolden EJ,Larson ED,Shechtman LA,Trahan GD,Gaillard D,Fellin TJ,Scott JK,Jones KL,Barlow LA
JournaleLife
PubMed ID34009125
Embryonic taste bud primordia are specified as taste placodes on the tongue surface and differentiate into the first taste receptor cells (TRCs) at birth. Throughout adult life, TRCs are continually regenerated from epithelial progenitors. Sonic hedgehog (SHH) signaling regulates TRC development and renewal, repressing taste fate embryonically, but promoting TRC ... More
Wheat Ms2 encodes for an orphan protein that confers male sterility in grass species.
Male sterility is a valuable trait for plant breeding and hybrid seed production. The dominant male-sterile gene Ms2 in common wheat has facilitated the release of hundreds of breeding lines and cultivars in China. Here, we describe the map-based cloning of the Ms2 gene and show that Ms2 confers male ... More
Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs.
Objective: To investigate the functions and potential molecular mechanism of LINC01296 regarding the progression of cutaneous malignant melanoma (CMM) by the regulation of miR-324-3p/MAPK1 axis. Methods: The candidate differential lncRNAs of CMM were selected from GEPIA database, and quantitative real-time PCR (qRT-PCR) was utilized to assess the expression level of ... More
Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
The type 2 diabetic phenotype results from mixed effects of insulin deficiency and insulin resistance, but the relative contributions of these two distinct factors remain poorly characterized, as do the respective roles of the gluconeogenic organs. The purpose of this study was to investigate localized in vivo metabolic changes in ... More
Complete replication-competent adenovirus 11p vectors with E1 or E3 insertions show improved heat stability.
AuthorsMei YF,Wu H,Hultenby K,Silver J
JournalVirology
PubMed ID27494367
Characterization of non-canonical G beta-like protein FvGbb2 and its relationship with heterotrimeric G proteins in Fusarium verticillioides.
AuthorsYan H,Shim WB
JournalEnvironmental microbiology
PubMed ID31760684
Aliskiren - a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS.
JournalGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
PubMed ID26939623
Melatonin-mediate acid rain stress tolerance mechanism through alteration of transcriptional factors and secondary metabolites gene expression in tomato.
AuthorsDebnath B,Li M,Liu S,Pan T,Ma C,Qiu D
JournalEcotoxicology and environmental safety
PubMed ID32470680
Expression of Mineralization Markers during Pulp Response to Biodentine and Mineral Trioxide Aggregate.
AuthorsDaltoé MO,Paula-Silva FW,Faccioli LH,Gatón-Hernández PM,De Rossi A,Bezerra Silva LA
JournalJournal of endodontics
PubMed ID26925520
Whole Blood Transcriptome Analysis for Lifelong Monitoring in Elite Sniffer Dogs Produced by Somatic Cell Nuclear Transfer.
AuthorsOck SA,Choi I,Im GS,Yoo JG
JournalCellular reprogramming
PubMed ID31633381
Characterization of class II β chain major histocompatibility complex genes in a family of Hawaiian honeycreepers: 'amakihi (Hemignathus virens).
AuthorsJarvi SI,Bianchi KR,Farias ME,Txakeeyang A,McFarland T,Belcaid M,Asano A
JournalImmunogenetics
PubMed ID26971289
A Markerless Gene Deletion System in Streptococcus suis by Using the Copper-Inducible Vibrio parahaemolyticus YoeB Toxin as a Counterselectable Marker.
AuthorsZheng C,Wei M,Qiu J,Li J
JournalMicroorganisms
PubMed ID34069706
Streptococcus suis is an important zoonotic pathogen causing severe infections in swine and humans. Induction of the Vibrio parahaemolyticus YoeB toxin in Escherichia coli resulted in cell death, leading to the speculation that YoeB(Vp) can be a counterselectable marker. Herein, the counterselection potential of YoeB(Vp) was assessed in S. suis. ... More
Recruitment of DNA to tumor-derived microvesicles.
AuthorsClancy JW,Sheehan CS,Boomgarden AC,D'Souza-Schorey C
JournalCell reports
PubMed ID35235806
The shedding of extracellular vesicles (EVs) represents an important but understudied means of cell-cell communication in cancer. Among the currently described classes of EVs, tumor-derived microvesicles (TMVs) comprise a class of vesicles released directly from the cell surface. TMVs contain abundant cargo, including functional proteins and miRNA, which can be ... More
Aminophylline promotes mitochondrial biogenesis in human pulmonary bronchial epithelial cells.
AuthorsWei G,Sun R,Xu T,Kong S,Zhang S
JournalBiochemical and biophysical research communications
PubMed ID31122698
The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3.
Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main contributor and independent risk factor for low back pain (LBP), it would be, therefore, enlightening that investigating the exact pathogenesis of IVDD and developing target-specific molecular drugs in the future. Ferroptosis is a new form of programmed cell ... More
Effects of copper sulphate and coated copper sulphate addition on lactation performance, nutrient digestibility, ruminal fermentation and blood metabolites in dairy cows.
The Monogenic Network of the Global Parkinsonâs Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinsonâs disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. ... More
Effects of testosterone on mean arterial pressure and aquaporin (AQP)-1, 2, 3, 4, 6 and 7 expressions in the kidney of orchidectomized, adult male Sprague-Dawley rats.
AuthorsLoh SY,Giribabu N,Gholami K,Salleh N
JournalArchives of biochemistry and biophysics
PubMed ID28024836
Effects of Carbocysteine and Beclomethasone on Histone Acetylation/Deacetylation Processes in Cigarette Smoke Exposed Bronchial Epithelial Cells.
SIMPLE SUMMARY: Currently, there is no consensus in the scientific literature regarding the zebrafish embryo xenotransplantation procedure for drug screening. Thus, this study sets systematic guidelines for maximizing the reproducibility of drug screening in zebrafish-embryo cancer xenograft models based on evaluating every step of the procedure in a real case ... More
Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta-thalassaemia intermedia and major phenotypes.
AuthorsMaia de Oliveira da Silva JP,Brugnerotto AF,S Romanello K,K L Teixeira K,Lanaro C,S Duarte A,G L Costa G,da Silva Araújo A,C Bezerra MA,de Farias Domingos I,Pereira Martins DA,Malavazi I,F Costa F,da Cunha AF
JournalBritish journal of haematology
PubMed ID31218684
In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity.
Coupling Transcriptomics and Behaviour to Unveil the Olfactory System of Spodoptera exigua Larvae.
AuthorsLlopis-Giménez A,Carrasco-Oltra T,Jacquin-Joly E,Herrero S,Crava CM
JournalJournal of chemical ecology
PubMed ID33150456
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
In recent years, the Zika Virus (ZIKV) has caused pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZS). Although all strains associated with worldwide outbreaks derive from the Asian lineage, the reasons for their enhanced spread and severity are not fully understood. In this study, we conducted ... More
IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes.
AuthorsKim GM,Kim J,Lee JY,Park MC,Lee SY
JournalExperimental & molecular medicine
PubMed ID38036734
Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the joints and is thus also accompanied by local inflammation, subchondral bone changes, and persistent pain. However, our understanding of the underlying subchondral bone dynamics during OA progression is ... More
Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
The protective role of NR4A3 in acute myocardial infarction by suppressing inflammatory responses via JAK2-STAT3/NF-κB pathway.
AuthorsJiang Y,Feng YP,Tang LX,Yan YL,Bai JW
JournalBiochemical and biophysical research communications
PubMed ID31399192
Scrodentoids H and I, a Pair of Natural Epimerides from Scrophularia dentata, Inhibit Inflammation through JNK-STAT3 Axis in THP-1 Cells.
AuthorsMao G,Sun L,Xu J,Li Y,Dunzhu C,Zhang L,Qian F
JournalEvidence-based complementary and alternative medicine : eCAM
PubMed ID32802115
BACKGROUND: Scrophularia dentata is an important medicinal plant and used for the treatment of exanthema and fever in Traditional Tibetan Medicine. Scrodentoids H and I (SHI), a pair of epimerides of C(19)-norditerpenoids isolated from Scrophularia dentata, could transfer to each other in room temperature and were firstly reported in our ... More
A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells.
AuthorsLi W,Itou J,Tanaka S,Nishimura T,Sato F,Toi M
JournalExperimental cell research
PubMed ID27032575
Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver.
AuthorsBarangi S,Mehri S,Moosavi Z,Hayesd AW,Reiter RJ,Cardinali DP,Karimi G
JournalEcotoxicology and environmental safety
PubMed ID32247962
Helicobacter Pylori-seropositivity along with genetic and environmental factors predicts clinical outcome after acute coronary syndrome.
p-STAT1 regulates the influenza A virus replication and inflammatory response in vitro and vivo.
AuthorsZhang S,Huo C,Xiao J,Fan T,Zou S,Qi P,Sun L,Wang M,Hu Y
JournalVirology
PubMed ID31493649
Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1.
AuthorsWilhelmi T,Xu X,Tan X,Hulshoff MS,Maamari S,Sossalla S,Zeisberg M,Zeisberg EM
JournalTheranostics
PubMed ID32226528
Rationale: Cardiac fibrosis is an integral constituent of every form of chronic heart disease, and persistence of fibrosis reduces tissue compliance and accelerates the progression to heart failure. Relaxin-2 is a human hormone, which has various physiological functions such as mediating renal vasodilation in pregnancy. Its recombinant form Serelaxin has ... More
Methods Evaluation for Rapid Concentration and Quantification of SARS-CoV-2 in Raw Wastewater Using Droplet Digital and Quantitative RT-PCR.
AuthorsFlood MT,D'Souza N,Rose JB,Aw TG
JournalFood and environmental virology
PubMed ID34296387
Wastewater surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging public health tool to understand the spread of Coronavirus Disease 2019 (COVID-19) in communities. The performance of different virus concentration methods and PCR methods needs to be evaluated to ascertain their suitability for use in the detection ... More
Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor β receptor II.
AuthorsLi Q,Li H,Lv Y,Zhang Q,Zhang X,Li S,Zheng X,Wang Y,Hao Z
JournalLaboratory investigation; a journal of technical methods and pathology
PubMed ID31641222
Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
HCC is the most common primary liver cancer and a leading cause of cancer-related mortality. Gut microbiota is a large collection of microbes, predominately bacteria, that harbor the gastrointestinal tract. Changes in gut microbiota that deviate from the native composition, that is, âdysbiosis,â is proposed as a probable diagnostic biomarker ... More
Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.
Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis (LAM) is a progressive pulmonary disease affecting almost exclusively women. TSC and LAM are both caused by mutations in TSC1 and TSC2 that result in mTORC1 hyperactivation. Here, we report that single-cell ... More
A novel cuproptosis-related lncRNAs signature predicts prognosis in bladder cancer.
AuthorsWu L,Chen W,Cao Y,Chen B,He Y,Wang X
JournalAging
PubMed ID37424068
This study constructed a novel cuproptosis-related lncRNAs signature to predict the prognosis of BLCA patients. The Cancer Genome Atlas (TCGA) database was used to retrieve the RNA-seq data together with the relevant clinical information. The cuproptosis-related genes were first discovered. The cuproptosis-related lncRNAs were then acquired by univariate, the least ... More
Characterization of magnesium doped sol-gel biomaterial for bone tissue regeneration: The effect of Mg ion in protein adsorption.
JournalMaterials science & engineering. C, Materials for biological applications
PubMed ID33965118
Protective influence of betaine on intestinal health by regulating inflammation and improving barrier function in broilers under heat stress.
AuthorsAlhotan RA,Al Sulaiman AR,Alharthi AS,Abudabos AM
JournalPoultry science
PubMed ID34329984
This research was executed to study the impacts of adding betaine (BT) to broiler diets on intestinal inflammatory response and barrier integrity under heat stress (HS). At 21 d of age, 150 male broilers (Ross 308) were randomly assigned to 3 treatment groups: control (CON) group, in which broilers were ... More
Impact of Mothers' Age on Telomere Length and Human Telomerase Reverse Transcriptase Expression in Human Fetal Membrane-Derived Mesenchymal Stem Cells.
AuthorsAlrefaei GI,Alkarim SA,Abduljabbar HS
JournalStem cells and development
PubMed ID31650883
Physiological characterization of leaf and internode after bud break in Japanese indigenous Koshu grape by comparative RNA sequencing analysis.
Koshu is indigenous to Japan and considered the most important wine grape in Japan. Koshu grape berry possesses characteristics that make it unique from European V. vinifera as wine grape. However, the physiological characteristics of Koshu leaf and internode remain unknown. An understanding of those characteristics would contribute to improvements ... More
Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer.
AuthorsLing HH,Kuo CC,Lin BX,Huang YH,Lin CW
JournalExperimental cell research
PubMed ID27914787
Inhibitory effect of trans-caryophyllene (TC) on leukocyte-endothelial attachment.
AuthorsZhang Z,Yang C,Dai X,Ao Y,Li Y
JournalToxicology and applied pharmacology
PubMed ID28624443
Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3.
AuthorsZhu XT,Yuan JH,Zhu TT,Li YY,Cheng XY
JournalThe FEBS journal
PubMed ID27573079
Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells.
AuthorsHolmstrøm K,Pedersen AE,Gad M
JournalScandinavian journal of immunology
PubMed ID27943367
Regulation of Complement-Dependent Cytotoxicity by MicroRNAs miR-200b, miR-200c, and miR-217.
AuthorsHillman Y,Mazkereth N,Farberov L,Shomron N,Fishelson Z
JournalJournal of immunology (Baltimore, Md. : 1950)
PubMed ID27183614
GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity.
JournalGenetics in medicine : official journal of the American College of Medical Genetics
PubMed ID28125083
PURPOSE: The aim of this study was to investigate the genetic basis and pathogenic mechanism of variable maculopathies, ranging from mild photoreceptor degeneration to central areolar choroidal dystrophy, in a five-generation family. METHODS: Clinical characterizations, whole-exome sequencing, and genome-wide linkage analysis were carried out on the family. Zebrafish models were ... More
Lycopene from Red Guava (Psidium guajava L.): From Hepatoprotective Effect to Its Use as Promising Self-Emulsifying Drug Delivery System for Anti-Inflammatory and Antioxidant Applications.
Lycopene is a carotenoid with potential use in the treatment of chronic illnesses. Here, different formulations of lycopene were studied: lycopene-rich extract from red guava (LEG), purified lycopene from red guava (LPG) and a self-emulsifying drug delivery system loaded with LPG (nanoLPG). The effects of administering orally various doses of ... More
Mulching practices alter the bacterial-fungal community and network in favor of soil quality in a semiarid orchard system.
AuthorsWang Y,Liu L,Luo Y,Awasthi MK,Yang J,Duan Y,Li H,Zhao Z
JournalThe Science of the total environment
PubMed ID32304971
Montelukast inhibits oxidized low-density lipoproteins (ox-LDL) induced vascular endothelial attachment: An implication for the treatment of atherosclerosis.
AuthorsDi X,Tang X,Di X
JournalBiochemical and biophysical research communications
PubMed ID28246014
The adrenal gland circadian clock exhibits a distinct phase advance in spontaneously hypertensive rats.
AuthorsTanaka S,Ueno T,Tsunemi A,Nagura C,Tahira K,Fukuda N,Soma M,Abe M
JournalHypertension research : official journal of the Japanese Society of Hypertension
PubMed ID30464218
WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice.
AuthorsTong Y,Yu Z,Zhang R,Ding X,Chen Z,Li Q
JournalBMC pulmonary medicine
PubMed ID30522479
BACKGROUND: Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca(2+) overload and neutrophil infiltration, have been implied in the pathogenesis of liver and remote organ injuries following reperfusion. WNT1 ... More
Proteomic and Global DNA Methylation Modulation in Lipid Metabolism Disorders with a Marine-Derived Bioproduct.
SIMPLE SUMMARY: Dyslipidemia is a significant risk factor for cardiovascular disease, and current treatments such as statins can have toxic side effects. RCI-1502, a bioproduct derived from the European S. pilchardus, has shown potential as a natural and less toxic alternative treatment for cardiovascular disorders. Alterations in DNA methylation patterns ... More
Genome-wide transcriptome analysis of female-sterile rice ovule shed light on its abortive mechanism.
AuthorsYang L,Wu Y,Yu M,Mao B,Zhao B,Wang J
JournalPlanta
PubMed ID27357232
Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin: A large prospective trial.
Reduction of caloric intake delays and prevents age-associated diseases and extends the life span in many organisms. It may be that these benefits are due to positive effects of caloric restriction on stem cell function. We use the planarian model Schmidtea mediterranea, an immortal animal that adapts to long periods ... More