These 96-well plates are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment. The panel of assays in the TaqMan® Array 96-well Human Hypoxia Plate targets genes in the HIF (hypoxia inducible factor) family. On the panel are the genes VHL, Cul2, and RBX1 (Ring-Box 1) that complex with additional genes for a role in the ubiquitylation of HIF1A. Other hypoxia response related genes fall in to the following target classes: Transcription Factors, Immune and Stress Response, Signal Transduction, Apoptosis, Oxidoreductases, Proteases, and Protein metabolism.