Covaris® M220 Focused-ultrasonicator™ Instrument

Catalog number: 4482277

Ion Torrent™  Related applications: Ion Torrent™ Next-Generation Sequencing

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The Covaris® M220 Focused-ultrasonicator™ is designed for next generation sequencing applications that require high-quality DNA fragmentation for library preparation. The Covaris® M220 efficiently focuses the minimum amount of energy required directly into a sample, enabling precise control of the hydrodynamic shearing forces that fragment nucleic acids to the selected size. The process is isothermal, so fragmentation is unbiased, the sample is undamaged, and yields are high. The Covaris® focused-ultrasonic technology is considered a DNA shearing standard in many labs worldwide.

The Covaris® M220 Focused-ultrasonicator™ is:

Easy: intuitive and robust design, no training needed
Fast: ready to go in less than 2 minutes, typical protocol takes 80 seconds
Versatile: select fragment distributions from 150 bp to 5 kb
Self-contained: integrated temperature control, no ice or external chiller needed
Quiet: can be used anywhere in the lab, sound shield included
Convenient: an integrated bench-top instrument with no external accessories

Covaris® Adaptive Focused Acoustics® (AFA) Technology
Covaris® AFA technology transmits acoustic energy at ultrasonic frequencies (500 KHz) and very short wavelengths (~3 mm), focusing the energy into the sample and precisely controlling the shearing forces that fragment nucleic acids to the selected size. The process is isothermal, non-contact, and quiet. AFA technology is at the core of all Covaris® instruments, including the high-throughput E- and L-Series used in leading genome centers worldwide.

SonoLab® Software
The Covaris® M220 is controlled though SonoLab® software. The software includes DNA shearing protocols for 50 and 130 µl samples and for fragment-size distributions ranging from 150 to 5,000 bp, as well as chromatin shearing protocols. Updated protocols can be downloaded directly from SonoLab® software also stores historical information. For every sample processed, Date and Time, User Name, AFA Settings, Actual Power Delivered, Bath Temperature, and customizable Sample Notes are recorded, so sample tracking is easy.

Integrated Instrument
Integrated cooling, powerful software control, and the Covaris® AFA focused-ultrasonic technology make the Covaris® M220 an extremely easy-to-use instrument that will consistently generate high-quality fragment distributions day-to-day and user-to-user, regardless of sample mass or GC content.

Versatile Tool
Ultra-precise control of the acoustic energy delivered to the sample by the Covaris® M220 Focused-ultrasonicator™ provides great versatility. For example, this instrument can be used for a wide range of applications, including DNA shearing, chromatin shearing, RNA shearing, DNA extraction from FFPE samples, and biomarker extraction from tissue samples.

The M220 Focused-ultrasonicator™ includes an integrated thermo-electric temperature controller, a computer, and Sonolab® software. miniTUBE or microTUBE Accessory Kits are specific to the application and may be purchased separately (see below).

Covaris® M220 Focused-ultrasonicator™ Kits
For DNA shearing into fragments smaller than 1.5 kb and chromatin shearing:
M220 microTUBE Accessory Kit
For DNA shearing into fragments larger than 1.5 kb:
M220 miniTUBE Accessory Kit
For Research Use Only. Not for use in diagnostic procedures.


Product Size: 1 instrument
For Use With (Equipment): Ion PGM™ System
High Throughput Compatibility: Not High Throughput-Compatible (Manual)

Contents & storage

Store at room temperature


Manuals & protocols