Ion Reporter™ Server System

Catalog number: 4487118

Ion Torrent™  Related applications: Ion Torrent™ Next-Generation Sequencing

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Description

The Ion Reporter Server System is a combined hardware and software solution for analyzing human and bacterial sequencing data. It consists of a locally deployed computer with a suite of informatics tools that streamlines and simplifies analysis, annotation, and archiving of semiconductor sequencing data from any Ion Torrent sequencer. The Ion Reporter Server System combines the ease of use of Ion Reporter Software with the control and access of a powerful computer server in your own building. A locally deployed computer affords many benefits, such as tighter control of the hardware and software versioning. In addition, data uploads from the Torrent Server are faster when the transfer is within your own network. With your own hardware, you have access to unlimited analyses, as well as more options for integration into your lab's workflow.

Streamlined integration with Ion Torrent next-generation sequencing systems
The Ion Reporter Server System is built to complete the next-generation sequencing workflow from sequencing data to report. This platform builds on the sample processing and sequencing output from the Ion S5, Ion S5 XL, Ion PGM, and Ion Proton systems by coupling tightly with the Torrent Server for data transfer and analysis initiation. When a sequencing run is started, an Ion Reporter Software workflow can be pre-designated so the data transfer and analysis are initiated seamlessly, eliminating the hands-on time between run initiation and reviewing annotated variants, with a host of annotations added to guide understanding.

Flexible analyses with controlled pipelines
Many research applications, including applications in the areas of oncology, inherited disease, reproductive health, and 16S bacterial metagenomics, are supported within Ion Reporter Software using pre-tuned, customizable analysis workflows. These workflows can be used to analyze single samples, paired tumor/normal samples, and family trios. Detect germline or somatic SNPs, indels, gene fusions, and CNVs in a single workflow. Use algorithms designed for oncological somatic variant detection, liquid biopsy cfDNA variant detection, and others designed specifically for low-pass whole-genome copy number for aneuploidy detection and inherited disease research applications. The analysis workflows designed around targeted sequencing have been specifically developed for Ion AmpliSeq gene panels and Oncomine assays. Ion Reporter Software also includes a 16S metagenomics workflow, which enables environmental and clinical researchers interested in bacterial populations to identify and classify the relative proportions of microbes present at any taxonomic level from one or multiple mixed populations.

Each of the Ion Reporter Software workflows can be used as pre-configured or modified and then locked for controlled use without the need for an analyst or bioinformatician. Alternatively, the platform is extensible with our software APIs to drive integration with your lab environment and processes. By integrating detected variants with comprehensive public and Ion Torrent proprietary annotations and your own lab-specific content, Ion Reporter Software helps reduce your bioinformatics work and the time needed to interpret your results. The analysis modules and parameters are configurable, allowing you to customize the workflow to fit your research needs. Workflows are open for development and testing, and may be locked for repeated use in an auditable production environment when desired. These features make Ion Reporter Software an ideal solution for clinical researchers needing a simple bioinformatics tool that helps ensure consistency of results.

Workflows follow intuitive steps
The Ion Reporter Software workflow steps mirror the typical role-based sample processing workflow used by most labs. Sequencing reads from Ion S5, Ion S5 XL, Ion PGM, or Ion Proton systems are automatically imported from the Torrent Browser into the local Ion Reporter Software environment for read mapping, variant detection, multi-sample analysis, and annotation. You can then filter the identified variants based on technical criteria such as read coverage, P-value, allele frequency, and a growing set of annotations such as gene names, conservation scores, COSMIC, OMIM and other public and proprietary classifications. After you classify and interpret the variants, Ion Reporter Software displays this summary in an easily readable report alongside the relevant variants and their corresponding annotations.

Ion Reporter Software can also be used for long-term data management and access to individual files and audit logs. The computer server enables Ion Reporter Software to provide scalable analysis and control of your data and results. In addition, the software is designed to the same robust data security standards as described in the HIPAA implementation guidelines.

Services and support
Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

For more information about the Ion Reporter Server System and related products, please download the Ion Reporter Server System flyer below.

For Research Use Only. Not for use in diagnostic procedures.

Specifications

For Use With (Equipment): Ion PGM™ System, Ion Proton™ System, Ion S5™ System, Ion S5™ XL System
Software Type: Informatics Tools
Operating System: Ubuntu 14.04
Product Line: Ion Reporter™ Software
Product Size: 1 each
Software Category: Analysis

Contents & storage

• Ion Reporter™ Software, includes first year software license
• 1 Dell T430 compute server
• Field installation of compute server and software

Documents

Manuals & protocols