Finasteride, 98%

Finasteride, CAS # 98319-26-7, is a 5α-reductase inhibitor that blocks conversion of testosterone and inhibits neurosteroid production.

Catalog Number	Quantity
458000050	5g

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Catalog number 458000050

Price (USD)

633.00

Quantity:

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Price (USD)

633.00

Chemical Identifiers

CAS98319-26-7

IUPAC Name(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H,11H,11aH-indeno[5,4-f]quinoline-7-carboxamide

Molecular FormulaC23H36N2O2

InChI KeyDBEPLOCGEIEOCV-WSBQPABSSA-N

SMILESCC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C

Specifications

Appearance (Color)White to beige

Infrared spectrumConforms

HPLC>=97.5 %

Water=<0.5 %

Appearance (Form)Crystalline powder

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Finasteride is an inhibitor of the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT)

• Finasteride also has been explored in neuroscience, as 5α-reductase enzymes are present in the central nervous system

• Finasteride has been seen to cross the blood-brain barrier and block production of neurosteroids

Applications

• Finasteride is mainly used in studies of prostate hyperplasia and tumors in mice, and can be studied in vitro or in vivo for its effects on hyperplasia, proliferation, and antioxidant activity

• Its activity has also been explored in brain, liver and testis tissues

• In vivo injection of finasteride has been shown to decrease neurogenesis and influence neuronal plasticity in mice

RUO – Research Use Only

Literature references

Kim, H.J.; Kim, T.J.; Kim, Y.G.; Seong, C.; Cho, J.H.; Kim, W.; Lee, K.H.; Kim, D.Y. Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Pharmaceutics. 2021, 13(9), 1410.

Chhipa, R.R.; Halim, D.; Cheng, J.; Zhang, H.Y.; Mohler, J.L.; Ip, C.; Wu, Y. The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific. Prostate. 2013, 73(14), 1483-94.

Römer, B.; Pfeiffer, N.; Lewicka, S.; Ben-Abdallah, N.; Vogt, M.A.; Deuschle, M.; Vollmayr, B.; Gass, P. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Pharmacopsychiatry. 20100, 43(5), 174-8.