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Proteintech
SMURF1 Polyclonal Antibody
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Product Details
55175-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to SMURF1.
Target Information
Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e. g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin ligase SMURF1; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; hSMURF1; hSMURF2; SMAD ubiquitination regulatory factor 1; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1
Gene Aliases: 4930431E10Rik; KIAA1625; mKIAA1625; RGD1309707; SMURF1
UniProt ID: (Human) Q9HCE7, (Mouse) Q9CUN6
Entrez Gene ID: (Human) 57154, (Rat) 690516, (Mouse) 75788
ubiquitin-protein transferase activity
transforming growth factor beta receptor binding
protein binding
phospholipid binding
transferase activity
SMAD binding
ubiquitin protein ligase activity
I-SMAD binding
R-SMAD binding
activin receptor binding
ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein export from nucleus
ectoderm development
protein ubiquitination
cell differentiation
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
receptor catabolic process
negative regulation of activin receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of axon extension
Wnt signaling pathway, planar cell polarity pathway
engulfment of target by autophagosome
substrate localization to autophagosome
protein targeting to vacuole involved in autophagy
protein localization to plasma membrane
positive regulation of dendrite extension
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
transforming growth factor beta receptor signaling pathway
biological_process
negative regulation of ossification
regulation of axon extension
ubiquitin-dependent SMAD protein catabolic process
protein localization to cell surface
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of defense response to virus by host
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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