Pharma 24 Twin-Screw Extruder

Catalog number: 553-2039

Pharma 24 Twin-Screw Extruder

Catalog number: 553-2039
The Thermo Scientific™ Pharma 24 Twin-Screw Extruder, with avaialble HME and Twin-Screw Granulation (TSG) Application Sets, is ideal for continuous processing in research, development or production in the pharmaceutical industry. The Pharma 24 extruder drives reduced clean room area, consistent and controllable processing, reduced product changeover time, on-demand production, minimized scale-up risk and reliable cleaning. It is suitable for process analytical technology (PAT).
 
Catalog Number
553-2039
Unit Size
Each
Item Description
Pharma 24 Twin-Screw Extruder - base instrument for processing pharmaceutical formulations
Price (USD)
Full specifications
BarrelBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward. Main feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports.
Barrel Bore Diameter24 mm
DescriptionPharma 24 Extruder processes pharmaceutical formulations at feed rates up to 20 kg/h (HME) and 70 kg/h (TSG)
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - base instrument for processing pharmaceutical formulations
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
Catalog Number
Unit Size
Each
Item Description
Pharma 24 Twin-Screw Extruder - TSG Application Set
Price (USD)
Full specifications
BarrelMain feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports
Barrel Bore Diameter24mm
Screw TypeSet of screw shafts fully configured with a suitable screw configuration, elements manufactured from corrosion resistant hardenable pharma grade steel
DescriptionBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward Open discharge chute with manually operated diverter valve for good/waste material Waste/sample collecting bins
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - TSG Application Set
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
Catalog Number
Unit Size
Each
Item Description
Pharma 24 Twin-Screw Extruder - HME Application Set
Price (USD)
Full specifications
BarrelBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward. Main feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports
Barrel Bore Diameter24mm
Screw TypeSet of screw shafts fully configured with a suitable screw configuration; elements manufactured from corrosion resistant hardenable pharma grade steel
DescriptionDie heater Die control temperature sensor Die adapter
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - HME Application Set
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
Showing 3 of 3
Catalog NumberSpecificationsUnit SizeItem DescriptionPrice (USD)
553-2039Full specifications
EachPharma 24 Twin-Screw Extruder - base instrument for processing pharmaceutical formulationsRequest A Quote
BarrelBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward. Main feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports.
Barrel Bore Diameter24 mm
DescriptionPharma 24 Extruder processes pharmaceutical formulations at feed rates up to 20 kg/h (HME) and 70 kg/h (TSG)
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - base instrument for processing pharmaceutical formulations
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
553-2037Full specifications
EachPharma 24 Twin-Screw Extruder - TSG Application Set Request A Quote
BarrelMain feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports
Barrel Bore Diameter24mm
Screw TypeSet of screw shafts fully configured with a suitable screw configuration, elements manufactured from corrosion resistant hardenable pharma grade steel
DescriptionBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward Open discharge chute with manually operated diverter valve for good/waste material Waste/sample collecting bins
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - TSG Application Set
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
553-2038Full specifications
EachPharma 24 Twin-Screw Extruder - HME Application SetRequest A Quote
BarrelBarrel designed with removable top and bottom liners made from pharma grade steel, horizontally split, with top half lifting upward. Main feed port (cooled) plus 7 multi-purpose top feed/vent/injection ports
Barrel Bore Diameter24mm
Screw TypeSet of screw shafts fully configured with a suitable screw configuration; elements manufactured from corrosion resistant hardenable pharma grade steel
DescriptionDie heater Die control temperature sensor Die adapter
Max. Torque105 Nm ( 2 x 52,5 Nm)
Item DescriptionPharma 24 Twin-Screw Extruder - HME Application Set
Electrical RequirementsPower connection 400 V 3PH+N+PE, 50/60 Hz and Power consumption 50 A
Dimensions (L x W x H)2075mm x 875mm x 1630mm
InterfaceIncludes touch screen control panel; Siemens PLC; Standard HMI languages: German and English (optional languages on request); 21 CFR part 11 compliance; Four different user levels with predefined access rights
Unit SizeEach
Showing 3 of 3
The Pharma 24 Twin-Screw Extruder features:
  • A small footprint to take up less space in clean rooms
  • Continuous operation which consumes fewer utilities than traditional batch processes
  • High free volume screw design
  • A small process inventory
  • Lower ingredient consumption which reduces handling and operator exposure
  • Segmented screws and barrel
  • Removable screws and liners
PAT Compatibility: PAT can be applied to your process to monitor parts of theprocess such as homogeneity of mixing or moisture content to assure required product quality. The Pharma 24 Extruder can be used with a range of PAT instruments such as Thermo Scientific™ FT-NIR system.

Options: We offer a full range of GMP compliant ancillaries which are matched to the extruder performance. This downstream equipment can be integrated into the extruder control system.

For TSG configurations: available ancillaries include volumetric or gravimetric dosing feeders and liquid injection pumps.

In addition, self-contained units of either configuration can be operated with recirculating chillers to reduce water consumption.

TSG configuration recommended for:
  • Wet granulation
  • Dry/melt granulation
For HME configurations: available ancillaries include volumetric or gravimetric dosing feeders, air cooled conveyors for product cooling, strand and face-cut pelletizers to make pellets, or chill roll/flaker units for rapid product cooling and flaking.

HME configuration recommended for:
  • Solubility enhancement
  • Modified release
  • Co-extrusion
  • Drug delivery systems
  • Biomedical products

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Frequently asked questions (FAQs)

Citations & References