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Proteintech

VCP Monoclonal Antibody (2A4B10)

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VCP Monoclonal Antibody (2A4B10)

Product Details

60316-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:20-1:200
View 2 publications 2 publications

ChIP assay (ChIP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2A4B10

Immunogen

VCP Fusion Protein Ag1002 (507-806 aa encoded by BC007562)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.67 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GMTPSKGVL FYGPPGCGKT LLAKAIANEC QANFISIKGP ELLTMWFGES EANVREIFDK ARQAAPCVLF FDELDSIAKA RGGNIGDGGG AADRVINQIL TEMDGMSTKK NVFIIGATNR PDIIDPAILR PGRLDQLIYI PLPDEKSRVA ILKANLRKSP VAKDVDLEFL AKMTNGFSGA DLTEICQRAC KLAIRESIES EIRRERERQT NPSAMEVEED DPVPEIRRDH FEEAMRFARR SVSDNDIRKY EMFAQTLQQS RGFGSFRFPS GNQGGAGPSQ GSGGGTGGSV YTEDNDDDLY G (507-806 aa encoded by BC007562)

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; homolog of yeast cdc48; Inv protein; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; unnamed protein product; Valosin-containing protein; VCP

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Gene Aliases: 3110001E05; CDC48; FTDALS6; HEL-220; HEL-S-70; p97; p97/VCP; TERA; VCP

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UniProt ID: (Human) P55072, (Mouse) Q01853

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Entrez Gene ID: (Human) 7415, (Mouse) 269523

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Function(s)
nucleotide binding RNA binding protein binding ATP binding lipid binding hydrolase activity ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding macromolecular complex binding ubiquitin-dependent protein binding BAT3 complex binding ubiquitin-specific protease binding receptor binding protein complex binding poly(A) RNA binding
Process(es)
DNA repair double-strand break repair ubiquitin-dependent protein catabolic process transport ER to Golgi vesicle-mediated transport activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization positive regulation of protein catabolic process protein homooligomerization aggresome assembly ER-associated misfolded protein catabolic process positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity autophagy I-kappaB kinase/NF-kappaB signaling proteasomal protein catabolic process positive regulation of mitochondrial membrane potential macroautophagy NAD metabolic process endoplasmic reticulum unfolded protein response endosome to lysosome transport via multivesicular body sorting pathway cellular response to heat negative regulation of hippo signaling stress granule disassembly interstrand cross-link repair ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization negative regulation of smoothened signaling pathway ATP metabolic process regulation of synapse organization mitotic spindle disassembly endoplasmic reticulum stress-induced pre-emptive quality control cellular response to misfolded protein flavin adenine dinucleotide catabolic process positive regulation of canonical Wnt signaling pathway autophagosome maturation protein-DNA covalent cross-linking repair negative regulation of protein localization to chromatin cytoplasm protein quality control positive regulation of NIK/NF-kappaB signaling regulation of aerobic respiration cellular response to arsenite ion positive regulation of oxidative phosphorylation regulation of protein localization to chromatin positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of ATP biosynthetic process
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