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Proteintech

Insulin Monoclonal Antibody (4B6A7)

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Insulin Monoclonal Antibody (4B6A7)

Product Details

66198-1-IG

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:10,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
View 18 publications 18 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

4B6A7

Immunogen

Insulin Fusion Protein Ag8630 (1-110 aa encoded by BC005255)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.23 mg/mL

Amount

184.5 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MALWMRLLP LLALLALWGP DPAAAFVNQH LCGSHLVEAL YLVCGERGFF YTPKTRREAE DLQVGQVELG GGPGAGSLQP LALEGSLQKR GIVEQCCTSI CSLYQLENYC N (1-110 aa encoded by BC005255)

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ins; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; Insulin-2; preproinsulin; proinsulin

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Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; PNDM4; proinsulin

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UniProt ID: (Human) P01308, (Mouse) P01325, (Mouse) P01326

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Entrez Gene ID: (Human) 3630, (Mouse) 16333, (Mouse) 16334

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Function(s)
protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity protein binding identical protein binding receptor agonist activity chaperone binding protein complex binding growth factor
Process(es)
positive regulation of cytokine production negative regulation of acute inflammatory response glucose metabolic process regulation of transcription, DNA-templated acute-phase response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of gene expression negative regulation of gene expression positive regulation of nitric oxide mediated signal transduction positive regulation of neuron projection development positive regulation of cell growth positive regulation of cell migration regulation of protein localization nitric oxide-cGMP-mediated signaling pathway TORC1 signaling wound healing negative regulation of protein catabolic process vasodilation glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process positive regulation of translation negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation positive regulation of lipid biosynthetic process regulation of synaptic plasticity regulation of protein secretion negative regulation of protein secretion positive regulation of protein secretion cognition negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of peptide hormone secretion positive regulation of brown fat cell differentiation positive regulation of protein localization to nucleus positive regulation of long-term synaptic potentiation cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of feeding behavior carbohydrate metabolic process glucose transport negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity regulation of cellular amino acid metabolic process ER overload response activation of JUN kinase activity myoblast fusion regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling myotube differentiation lipid catabolic process regulation of transmembrane transporter activity activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization negative regulation of NAD(P)H oxidase activity regulation of phosphorylation regulation of protein binding positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication negative regulation of proteolysis positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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