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MYOD1 Monoclonal Antibody (5D1D12)

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View all (47) MYOD antibodies

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MYOD1 Monoclonal Antibody (5D1D12)

Product Details

66214-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 4 publications 4 publications
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5D1D12

Immunogen

MYOD1 Fusion Protein Ag13512 (1-320 aa encoded by BC064493)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.47 mg/mL

Amount

220.5 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MELLSPPLR DVDLTAPDGS LCSFATTDDF YDDPCFDSPD LRFFEDLDPR LMHVGALLKP EEHSHFPAAV HPAPGAREDE HVRAPSGHHQ AGRCLLWACK ACKRKTTNAD RRKAATMRER RRLSKVNEAF ETLKRCTSSN PNQRLPKVEI LRNAIRYIEG LQALLRDQDA APPGAAAAFY APGPLPPGRG GEHYSGDSDA SSPRSNCSDG MMDYSGPPSG ARRRNCYEGA YYNEAPSEPR PGKSAAVSSL DCLSSIVERI STESPAAPAL LLADVPSESP PRRQEAAAPS EGESSGDPTQ SPDAAPQCPA GANPNPIYQV L (1-320 aa encoded by BC064493)

Target Information

The Myogenic determination gene (MyoD) was first identified by the virtue of its ability to convert embryonic mouse fibroblast cells to muscle cells. It was subsequently shown that forced expression of MyoD (human homolog is myf 3) gene in a wide variety of normal and neoplastic cells could either convert the cells to muscle cells or activate a set of the otherwise transcriptionally inactive muscle-specific genes in these cells. The regulatory domain of the MyoD gene product lies within a 70 amino acid region and comprises a basic DNA binding motif and a helix-loop-helix (HLH) dimerization motif. Subsequent studies identified three other genes whose products shared sequence homology for the basic HLH domain of MyoD. These are; myf5, myogenin (human homolog is myf4) and myf6 (also known as MRF4 and herculin).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: bHLHc1; Class C basic helix-loop-helix protein 1; eukaryotic myogenic factor MYF-3; Myf-3; Myoblast determination protein 1; MyoD; Myogenic factor 3; myogenic regulatory factor; unnamed protein product

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Gene Aliases: AI503393; BHLHC1; CMYO17; CMYP17; MUF3; MYF-3; MYF3; MYOD; Myod-1; MYOD1; MYODRIF; PUM

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UniProt ID: (Pig) P49811, (Human) P15172, (Mouse) P10085, (Rat) Q02346

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Entrez Gene ID: (Pig) 407604, (Human) 4654, (Mouse) 17927, (Rat) 337868

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Function(s)
DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor binding chromatin DNA binding protein dimerization activity E-box binding promoter-specific chromatin binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding ligand-dependent nuclear receptor binding enzyme binding ubiquitin protein ligase binding protein homodimerization activity bHLH transcription factor binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding core promoter binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding nuclear hormone receptor binding protein heterodimerization activity basic helix-loop-helix transcription factor
Process(es)
regulation of alternative mRNA splicing, via spliceosome transcription, DNA-templated muscle organ development myoblast fate determination skeletal muscle tissue development positive regulation of skeletal muscle tissue regeneration histone H3 acetylation histone H4 acetylation myoblast differentiation positive regulation of transcription from RNA polymerase II promoter striated muscle cell differentiation positive regulation of muscle cell differentiation cellular response to estradiol stimulus positive regulation of snRNA transcription by RNA polymerase II regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation myoblast fusion cellular response to starvation tissue development regulation of gene expression myotube differentiation myotube cell development myotube differentiation involved in skeletal muscle regeneration cell differentiation skeletal muscle cell differentiation muscle cell differentiation muscle cell fate commitment skeletal muscle tissue regeneration regulation of RNA splicing skeletal muscle fiber adaptation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated animal organ development skeletal muscle fiber development positive regulation of skeletal muscle fiber development cellular response to tumor necrosis factor cellular response to glucocorticoid stimulus cellular response to oxygen levels positive regulation of myoblast fusion negative regulation of myoblast proliferation multicellular organism development cardiac muscle cell differentiation skeletal muscle atrophy response to muscle stretch
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