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Proteintech
Gelsolin Monoclonal Antibody (3C4A2)
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Product Details
66280-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgA
Class
Monoclonal
Type
Antibody
Clone
3C4A2
Immunogen
Gelsolin Fusion Protein Ag17916 (433-782 aa encoded by BC026033)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAQHGMDD DGTGQKQIWR IEGSNKVPVD PATYGQFYGG DSYIILYNYR HGGRQGQIIY NWQGAQSTQD EVAASAILTA QLDEELGGTP VQSRVVQGKE PAHLMSLFGG KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN DAFVLKTPSA AYLWVGTGAS EAEKTGAQEL LRVLRAQPVQ VAEGSEPDGF WEALGGKAAY RTSPRLKDKK MDAHPPRLFA CSNKIGRFVI EEVPGELMQE DLATDDVMLL DTWDQVFVWV GKDSQEEEKT EALTSAKRYI ETDPANRDRR TPITVVKQGF EPPSFVGWFL GWDDDYWSVD PLDRAMAELA A (433-782 aa encoded by BC026033)
Target Information
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; epididymis secretory sperm binding protein; Gelsolin; RP11-477J21.1; unnamed protein product
Gene Aliases: ADF; AGEL; AMYLD4; GSN
UniProt ID: (Human) P06396
Entrez Gene ID: (Human) 2934
phagocytosis, engulfment
actin filament organization
central nervous system development
actin polymerization or depolymerization
positive regulation of gene expression
striated muscle atrophy
vesicle-mediated transport
extracellular matrix disassembly
cell projection organization
cell projection assembly
actin cytoskeleton organization
actin filament polymerization
actin filament depolymerization
protein destabilization
response to muscle stretch
positive regulation of apoptotic process
negative regulation of viral entry into host cell
actin filament severing
barbed-end actin filament capping
positive regulation of actin nucleation
actin filament capping
relaxation of cardiac muscle
cilium morphogenesis
cellular response to interferon-gamma
regulation of podosome assembly
cardiac muscle cell contraction
renal protein absorption
hepatocyte apoptotic process
positive regulation of keratinocyte apoptotic process
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of receptor clustering
positive regulation of protein processing in phagocytic vesicle
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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