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Proteintech
Phospho-TDP43 (Ser409, Ser410) Monoclonal Antibody (1A2C1)
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Product Details
66318-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2C1
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
66318-1-Ig is a phospho-dependent monoclonal antibody specifically recognizing phospho-TDP43 (409/410). It does not react with native TDP-43.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OTTHUMP00000002171; OTTHUMP00000002173; RP4-635E18.2; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TARDBP; TDP-43; unnamed protein product
Gene Aliases: 1190002A23Rik; ALS10; C85084; TARDBP; TDP-43; TDP43
UniProt ID: (Human) Q13148, (Mouse) Q921F2
Entrez Gene ID: (Human) 23435, (Mouse) 230908, (Rat) 298648
RNA polymerase II core promoter proximal region sequence-specific DNA binding
nucleic acid binding
DNA binding
double-stranded DNA binding
RNA binding
mRNA 3'-UTR binding
protein binding
lipid binding
identical protein binding
pre-mRNA intronic binding
molecular condensate scaffold activity
nucleotide binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
poly(A) RNA binding
negative regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mRNA processing
RNA splicing
negative regulation of gene expression
nuclear fragmentation involved in apoptotic nuclear change
negative regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
3'-UTR-mediated mRNA stabilization
nuclear inner membrane organization
positive regulation of insulin secretion
response to endoplasmic reticulum stress
gene expression
regulation of gene expression
regulation of protein stability
positive regulation of protein import into nucleus
regulation of circadian rhythm
regulation of apoptotic process
rhythmic process
3'-UTR-mediated mRNA destabilization
amyloid fibril formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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