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Proteintech
XRCC5 Monoclonal Antibody (2G5E7)
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Product Details
66546-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2G5E7
Immunogen
XRCC5 Fusion Protein Ag9512 (384-732 aa encoded by BC019027)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LDDLDMVAI VRYAYDKRAN PQVGVAFPHI KHNYECLVYV QLPFMEDLRQ YMFSSLKNSK KYAPTEAQLN AVDALIDSMS LAKKDEKTDT LEDLFPTTKI PNPRFQRLFQ CLLHRALHPR EPLPPIQQHI WNMLNPPAEV TTKSQIPLSK IKTLFPLIEA KKKDQVTAQE IFQDNHEDGP TAKKLKTEQG GAHFSVSSLA EGSVTSVGSV NPAENFRVLV KQKKASFEEA SNQLINHIEQ FLDTNETPYF MKSIDCIRAF REEAIKFSEE QRFNNFLKAL QEKVEIKQLN HFWEIVVQDG ITLITKEEAS GSSVTAEEAK KFLAPKDKPS GDTAAVFEEG GDVDDLLDMI (384-732 aa encoded by BC019027)
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein Ku80; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku (p70/p80) subunit; Ku antigen; Ku autoantigen protein p86 homolog; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku p80; Ku-80; Ku-86; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupu; lupus; Lupus Ku autoantigen protein p86; Nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; Thyroid-lupus autoantigen; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5
Gene Aliases: AI314015; G22P2; KARP-1; KARP1; KU80; Ku86; KUB2; Kup80; NFIV; XRCC5
UniProt ID: (Human) P13010, (Mouse) P27641
Entrez Gene ID: (Human) 7520, (Rat) 363247, (Mouse) 22596
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
helicase activity
protein binding
ATP binding
enzyme activator activity
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
ubiquitin protein ligase binding
U3 snoRNA binding
telomeric DNA binding
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
ATP-dependent DNA helicase activity
protein C-terminus binding
transcription regulatory region DNA binding
poly(A) RNA binding
hydrolase activity, acting on acid anhydrides
DNA helicase
telomere maintenance
recombinational repair
activation of innate immune response
immune system process
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
negative regulation of macromolecule biosynthetic process
neurogenesis
regulation of telomere maintenance
small-subunit processome assembly
ribosome biogenesis
innate immune response
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
regulation of smooth muscle cell proliferation
positive regulation of neurogenesis
hematopoietic stem cell differentiation
protein localization to chromosome, telomeric region
hematopoietic stem cell proliferation
cellular response to gamma radiation
negative regulation of t-circle formation
cellular response to leukemia inhibitory factor
brain development
cell proliferation
DNA duplex unwinding
response to drug
cellular response to fatty acid
cellular hyperosmotic salinity response
cellular response to X-ray
transcription, DNA-templated
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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