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Proteintech
TOM70 Monoclonal Antibody (1H8A1)
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Product Details
66593-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1H8A1
Immunogen
TOM70 Fusion Protein Ag6027 (245-608 aa encoded by BC052994)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KNREPLMPS PQFIKSYFSS FTDDIISQPM LKGEKSDEDK DKEGEALEVK ENSGYLKAKQ YMEEENYDKI ISECSKEIDA EGKYMAEALL LRATFYLLIG NANAAKPDLD KVISLKEANV KLRANALIKR GSMYMQQQQP LLSTQDFNMA ADIDPQNADV YHHRGQLKIL LDQVEEAVAD FDECIRLRPE SALAQAQKCF ALYRQAYTGN NSSQIQAAMK GFEEVIKKFP RCAEGYALYA QALTDQQQFG KADEMYDKCI DLEPDNATTY VHKGLLQLQW KQDLDRGLEL ISKAIEIDNK CDFAYETMGT IEVQRGNMEK AIDMFNKAIN LAKSEMEMAH LYSLCDAAHA QTEVAKKYGL KPPTL (245-608 aa encoded by BC052994)
Target Information
Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ90470; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; Translocase of outer mitochondrial membrane protein 70; unnamed protein product
Gene Aliases: 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; KIAA0719; mKIAA0719; TOM70; TOMM70; TOMM70A
UniProt ID: (Human) O94826, (Mouse) Q9CZW5, (Rat) Q75Q39
Entrez Gene ID: (Pig) 100523641, (Human) 9868, (Mouse) 28185, (Rat) 304017
activation of innate immune response
positive regulation of defense response to virus by host
protein targeting to mitochondrion
mRNA transcription
protein import into mitochondrial matrix
positive regulation of interferon-beta production
regulation of apoptotic process
protein import into mitochondrial inner membrane
protein import into mitochondrial outer membrane
negative regulation of cell growth involved in cardiac muscle cell development
response to thyroxine
cellular response to virus
antiviral innate immune response
positive regulation of protein targeting to mitochondrion
protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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