SETD7 Antibody

Catalog number: 730055

Invitrogen™  Related applications: Protein Assays and Analysis | Protein Purification & Isolation

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Description

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Specifications

Product Size: -
Material: Silicone
Length (English) Case: 49 ft.
Diameter (Metric) Inner: 4mm
Diameter (Metric) Outer: 8.0mm
Thickness (Metric) Wall: 2.0mm
Length (Metric) Case: 15m
Description: Silicone tubing
Thickness: 2.0mm
Internal Diameter: 4mm

Contents & storage

2 - 8 °C for up to 1 month, -20 °C for long storage.

Avoid repeated freezing and thawing.

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Manuals & protocols

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