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Antibodies Inc
KCC2 Monoclonal Antibody (N1/66), FL490
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Product Details
75-050-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N1/66
Immunogen
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (accession number Q63633) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Electroneutral potassium-chloride cotransporter 2; erythroid K-Cl cotransporter 2; Furosemide-sensitive K-Cl cotransporter; hKCC2; K-Cl cotransporter 2; KCC 2; KCC2a variant 1; KCC2a-S25 variant 1; KCC2b variant 2; mKCC2; Neuronal K-Cl cotransporter; neuronal-specific K-Cl cotransporter; rKCC2; S12A5; solute carrier family 12 (potassium/chloride transporter), member 5; Solute carrier family 12 member 5; solute carrier family 12, member 5; unnamed protein product
Gene Aliases: DEE34; EIEE34; EIG14; hKCC2; KCC2; KIAA1176; mKIAA1176; SLC12A5
UniProt ID: (Human) Q9H2X9, (Mouse) Q80TI5, (Rat) Q63633
Entrez Gene ID: (Chicken) 777252, (Human) 57468, (Mouse) 57138, (Rat) 171373
ammonium transmembrane transporter activity
chloride transmembrane transporter activity
symporter activity
cation:chloride symporter activity
potassium:chloride symporter activity
protein kinase binding
transmembrane transporter activity
metal ion binding
protein binding
secondary carrier transporter
ion transport
potassium ion transport
chloride transport
cell volume homeostasis
hypotonic response
chemical synaptic transmission
learning
response to xenobiotic stimulus
cellular chloride ion homeostasis
developmental process
multicellular organism growth
thermosensory behavior
intracellular pH reduction
chloride ion homeostasis
potassium ion homeostasis
transmembrane transport
dendritic spine development
potassium ion transmembrane transport
ammonium transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynapse assembly
chloride transmembrane transport
potassium ion import across plasma membrane
transport
organic cation transport
ammonium transport
response to drug
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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