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Prion Monoclonal Antibody 15B3

Catalog number: 7501003

 Related applications: Animal Health

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Description

The mouse monoclonal antibody 15B3 is a conformation-specific antibody that recognizes the disease-specific form of the prion protein (PrPSc) only. The IgM isotype antibody is capable of detecting PrPSc in brain homogenates without the need for proteinase K digestion. This is of considerable importance for its application in blood, as it has been shown that prion infectivity in blood is sensitive to protease digestion and therefore may not be detected in methods using protease digestion.
mAb 15B3 is used in immunoprecipitation experiments followed by detection using Western blotting, FACS analysis, or the real-time quaking-induced conversion procedure. Additionally, mAb 15B3 can be used as a capture antibody in sandwich ELISAs. A detailed immunoprecipitation protocol is sent with the product.
For Veterinary Use Only.

Specifications

Clonality: Monoclonal
Reactivity: Human, Sheep, Deer, Bovine
Host Species: Mouse
Product Size: 1 mg

Documents

Manuals & protocols